Matches in SemOpenAlex for { <https://semopenalex.org/work/W12695969> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W12695969 abstract "Background and Purpose - Extended release dipyridamole (ERD) is widely used in patients after ischemic stroke; however, the ability of this antithrombotic agent to be stored in different blood cells has never been explored in post-stroke patients. We hypothesized that since ERD is known to be highly lipophylic, the drug may be present not only in plasma, but also accumulated in platelets, leukocytes, and erythrocytes. Methods - Fifteen patients after documented ischemic stroke were treated with Aggrenox (ERD and low dose aspirin combination) BID for 30 days, and 12 of them completed the study. ERD concentrations in blood cells and platelet poor plasma were measured by spectrofluorimetry at Baseline, Day 14, and Day 30 after the initiation of therapy. Results - The background level of spectrofluorometry readings differs slightly among the blood components (132–211 ng/mL) due to the differences in the preparation of samples and cell isolation techniques. As expected, 2 weeks of ERD therapy produced steady state plasma concentration of dipyridamole already at Day 14 (1680±542ng/mL), followed by a slight not significant decrease at one month (1619±408). Two weeks of therapy was sufficient to achieve a consistent dipyridamole accumulation in erythrocytes (361±43), but not in platelets (244±78), or leukocytes (275±49). In fact, while blood cells continued dipyridamole intake beyond 14 days period, and this increase (398±66) was significant (p=0.02) at thirty days. Conclusion - Treatment with ERD in post-stroke patients resulted not only in the achieving of therapeutic plasma dipyridamole concentrations, but also deposition of the drug in erythrocytes and leukocytes, but not in platelets. If confirmed, these data will affect our better understanding of dipyridamole pleiotropy, and may expand future clinical indications of ERD formulation." @default.
- W12695969 created "2016-06-24" @default.
- W12695969 creator A5000582387 @default.
- W12695969 creator A5061207352 @default.
- W12695969 creator A5064742644 @default.
- W12695969 creator A5086088338 @default.
- W12695969 creator A5089833489 @default.
- W12695969 date "2009-11-03" @default.
- W12695969 modified "2023-09-26" @default.
- W12695969 title "Abstract 5134: Distribution of Dipyridamole in Blood Components Among Post-Stroke Patients Treated With Extended Release Formulation" @default.
- W12695969 hasPublicationYear "2009" @default.
- W12695969 type Work @default.
- W12695969 sameAs 12695969 @default.
- W12695969 citedByCount "0" @default.
- W12695969 crossrefType "journal-article" @default.
- W12695969 hasAuthorship W12695969A5000582387 @default.
- W12695969 hasAuthorship W12695969A5061207352 @default.
- W12695969 hasAuthorship W12695969A5064742644 @default.
- W12695969 hasAuthorship W12695969A5086088338 @default.
- W12695969 hasAuthorship W12695969A5089833489 @default.
- W12695969 hasConcept C126322002 @default.
- W12695969 hasConcept C127413603 @default.
- W12695969 hasConcept C1621761 @default.
- W12695969 hasConcept C2776890861 @default.
- W12695969 hasConcept C2777015399 @default.
- W12695969 hasConcept C2777628954 @default.
- W12695969 hasConcept C2780076745 @default.
- W12695969 hasConcept C2780645631 @default.
- W12695969 hasConcept C42219234 @default.
- W12695969 hasConcept C541997718 @default.
- W12695969 hasConcept C71924100 @default.
- W12695969 hasConcept C78519656 @default.
- W12695969 hasConcept C89560881 @default.
- W12695969 hasConcept C98274493 @default.
- W12695969 hasConceptScore W12695969C126322002 @default.
- W12695969 hasConceptScore W12695969C127413603 @default.
- W12695969 hasConceptScore W12695969C1621761 @default.
- W12695969 hasConceptScore W12695969C2776890861 @default.
- W12695969 hasConceptScore W12695969C2777015399 @default.
- W12695969 hasConceptScore W12695969C2777628954 @default.
- W12695969 hasConceptScore W12695969C2780076745 @default.
- W12695969 hasConceptScore W12695969C2780645631 @default.
- W12695969 hasConceptScore W12695969C42219234 @default.
- W12695969 hasConceptScore W12695969C541997718 @default.
- W12695969 hasConceptScore W12695969C71924100 @default.
- W12695969 hasConceptScore W12695969C78519656 @default.
- W12695969 hasConceptScore W12695969C89560881 @default.
- W12695969 hasConceptScore W12695969C98274493 @default.
- W12695969 hasLocation W126959691 @default.
- W12695969 hasOpenAccess W12695969 @default.
- W12695969 hasPrimaryLocation W126959691 @default.
- W12695969 hasRelatedWork W1521722640 @default.
- W12695969 hasRelatedWork W2032766118 @default.
- W12695969 hasRelatedWork W2033930761 @default.
- W12695969 hasRelatedWork W2054774535 @default.
- W12695969 hasRelatedWork W2076238851 @default.
- W12695969 hasRelatedWork W2082321356 @default.
- W12695969 hasRelatedWork W2153502661 @default.
- W12695969 hasRelatedWork W2186271804 @default.
- W12695969 hasRelatedWork W2192313369 @default.
- W12695969 hasRelatedWork W2253545720 @default.
- W12695969 hasRelatedWork W2316399502 @default.
- W12695969 hasRelatedWork W2398847406 @default.
- W12695969 hasRelatedWork W2402643006 @default.
- W12695969 hasRelatedWork W2412274245 @default.
- W12695969 hasRelatedWork W2419280368 @default.
- W12695969 hasRelatedWork W2419591438 @default.
- W12695969 hasRelatedWork W2419608205 @default.
- W12695969 hasRelatedWork W2437449150 @default.
- W12695969 hasRelatedWork W3152759509 @default.
- W12695969 hasRelatedWork W2189594703 @default.
- W12695969 hasVolume "120" @default.
- W12695969 isParatext "false" @default.
- W12695969 isRetracted "false" @default.
- W12695969 magId "12695969" @default.
- W12695969 workType "article" @default.