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- W1269796774 abstract "This chapter describes the biosynthesis of pteridines in drosophila melanogaster and rana catesbeiana. Using 14C-labeled compounds, the biosynthesis of biopterin is investigated in drosophila melanogasler and rana catesbeiana. A guanine nucleotide, neopterin, 2-amino-4-hydroxy-6- hydroxymethylpteridine and reduced 2-amino-4-hydroxypteridine serve as precursors of biopterin and that 7,8-dihydroneopterin 3'-phosphate or its pyrophosphate is a direct precursor of biopterin. Guanosine 5'-monophosphate (GMP) is an effective precursor of biopterin and 2-amino-4-hydroxypteridine (AHP); the specific radioactivities of the products are approximately the same. Neopterin is also converted into biopterin and 2-amino-4-hydroxypteridine, and again the specific radioaetivities of the products are essentially identical. 2-Amino- 4-hydroxy-6-hydroxymethylpteridine is effectively converted into 2-amino-4-hydroxypteridine and, to a lesser extent, into biopterin. The evidence presented suggests that there exists a main catabolic pathway for neopterin. A more possible direct precursor of biopterin and sepiapterin might be a 7, 8-dihydroneopterin compound. The incorporation of neopterin, 7, 8-dihydroneopterin, and neopterin 3'-phosphate into biopterin are compared." @default.
- W1269796774 created "2016-06-24" @default.
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- W1269796774 date "1971-01-01" @default.
- W1269796774 modified "2023-09-23" @default.
- W1269796774 title "[191] Biosynthesis of pteridines in Drosophila melanogaster and Rana catesbeiana" @default.
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- W1269796774 doi "https://doi.org/10.1016/s0076-6879(71)18148-7" @default.
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