FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W126987811> ?p ?o ?g. }

• W126987811 endingPage "769" @default.
• W126987811 startingPage "761" @default.
• W126987811 abstract "To examine the possibility that cytokines produced in inflamed joint tissues may contribute to the loss of articular cartilage by causing inhibition of synthesis of cartilage-specific matrix macromolecules, we studied the effects of interferon gamma (IFN gamma) and tumour necrosis factor alpha (TNF alpha), alone and in combination, on the expression of the genes for types-II, -IX and -XI collagens in cultured human chondrocytes. Chondrocytes isolated from human fetal epiphyseal cartilage by sequential enzymic digestions were cultured in the presence of IFN gamma (30 pM), TNF alpha (15 pM) or a combination of suboptimal concentrations of both cytokines (1.5 pM IFN gamma plus 0.3 pM TNF alpha). IFN gamma caused a maximal decrease of 23.3-32.6% in the biosynthesis of collagen by chondrocytes. TNF alpha was a more potent inhibitor causing a 42.8-45.3% decrease at one-half the concentration of IFN gamma. A synergistic inhibitory effect of 58.2% was observed with the combination of 1.5 pM IFN gamma plus 0.3 pM TNF alpha. Electrophoretic analysis of the biosynthesized proteins showed a co-ordinate decrease in the production of the three cartilage-specific collagen types II, IX and XI. These effects were accompanied by parallel changes in the steady-state levels of their corresponding mRNAs. In vitro transcription assays showed that the collagen inhibitory effects of the cytokines occurred largely at the transcriptional level. Similar effects of the cytokines were observed on biosynthesis of types-II, -IX and -XI collagens and steady-state mRNA levels for type-II collagen by chondrocytes obtained from adult articular cartilage. These observations indicate that IFN gamma and TNF alpha can induce a synergistic inhibition of the synthesis of cartilage-specific collagens by fetal and adult human chondrocytes and suggest that these effects may contribute to the articular cartilage loss that occurs in inflammatory joint diseases." @default.
• W126987811 created "2016-06-24" @default.
• W126987811 creator A5005902360 @default.
• W126987811 creator A5029317871 @default.
• W126987811 creator A5031590206 @default.
• W126987811 creator A5068172139 @default.
• W126987811 creator A5072236428 @default.
• W126987811 date "1993-09-15" @default.
• W126987811 modified "2023-09-27" @default.
• W126987811 title "Transcriptional modulation of cartilage-specific collagen gene expression by interferon <i>γ</i> and tumour necrosis factor <i>α</i> in cultured human chondrocytes" @default.
• W126987811 cites W1504458230 @default.
• W126987811 cites W1552812763 @default.
• W126987811 cites W1585071604 @default.
• W126987811 cites W1585615702 @default.
• W126987811 cites W1598530978 @default.
• W126987811 cites W175055053 @default.
• W126987811 cites W183541988 @default.
• W126987811 cites W1889799178 @default.
• W126987811 cites W1964149142 @default.
• W126987811 cites W1965544173 @default.
• W126987811 cites W1977779461 @default.
• W126987811 cites W1978455261 @default.
• W126987811 cites W1978950020 @default.
• W126987811 cites W1996794055 @default.
• W126987811 cites W1996803473 @default.
• W126987811 cites W1998868640 @default.
• W126987811 cites W2007451263 @default.
• W126987811 cites W2013962964 @default.
• W126987811 cites W2016297296 @default.
• W126987811 cites W2017720269 @default.
• W126987811 cites W2022640830 @default.
• W126987811 cites W2025986824 @default.
• W126987811 cites W2029987769 @default.
• W126987811 cites W2033123803 @default.
• W126987811 cites W2040951118 @default.
• W126987811 cites W2051819610 @default.
• W126987811 cites W2056191911 @default.
• W126987811 cites W2058267243 @default.
• W126987811 cites W2062510144 @default.
• W126987811 cites W2068406471 @default.
• W126987811 cites W2070662070 @default.
• W126987811 cites W2076663302 @default.
• W126987811 cites W2079161353 @default.
• W126987811 cites W2080955008 @default.
• W126987811 cites W2131115069 @default.
• W126987811 cites W2140769991 @default.
• W126987811 cites W2146555058 @default.
• W126987811 cites W2177943720 @default.
• W126987811 cites W238232679 @default.
• W126987811 cites W2407973100 @default.
• W126987811 cites W2415727144 @default.
• W126987811 cites W255028057 @default.
• W126987811 cites W271228137 @default.
• W126987811 doi "https://doi.org/10.1042/bj2940761" @default.
• W126987811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1134527" @default.
• W126987811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8379931" @default.
• W126987811 hasPublicationYear "1993" @default.
• W126987811 type Work @default.
• W126987811 sameAs 126987811 @default.
• W126987811 citedByCount "58" @default.
• W126987811 countsByYear W1269878112012 @default.
• W126987811 countsByYear W1269878112014 @default.
• W126987811 countsByYear W1269878112015 @default.
• W126987811 countsByYear W1269878112016 @default.
• W126987811 countsByYear W1269878112017 @default.
• W126987811 countsByYear W1269878112018 @default.
• W126987811 countsByYear W1269878112019 @default.
• W126987811 countsByYear W1269878112021 @default.
• W126987811 countsByYear W1269878112022 @default.
• W126987811 countsByYear W1269878112023 @default.
• W126987811 crossrefType "journal-article" @default.
• W126987811 hasAuthorship W126987811A5005902360 @default.
• W126987811 hasAuthorship W126987811A5029317871 @default.
• W126987811 hasAuthorship W126987811A5031590206 @default.
• W126987811 hasAuthorship W126987811A5068172139 @default.
• W126987811 hasAuthorship W126987811A5072236428 @default.
• W126987811 hasBestOaLocation W1269878112 @default.
• W126987811 hasConcept C104317684 @default.
• W126987811 hasConcept C105580179 @default.
• W126987811 hasConcept C105702510 @default.
• W126987811 hasConcept C126322002 @default.
• W126987811 hasConcept C150194340 @default.
• W126987811 hasConcept C153911025 @default.
• W126987811 hasConcept C17991360 @default.
• W126987811 hasConcept C185592680 @default.
• W126987811 hasConcept C202751555 @default.
• W126987811 hasConcept C203014093 @default.
• W126987811 hasConcept C2778690821 @default.
• W126987811 hasConcept C2780550940 @default.
• W126987811 hasConcept C2780841837 @default.
• W126987811 hasConcept C2781403057 @default.
• W126987811 hasConcept C503630168 @default.
• W126987811 hasConcept C55493867 @default.
• W126987811 hasConcept C71924100 @default.
• W126987811 hasConcept C86803240 @default.
• W126987811 hasConceptScore W126987811C104317684 @default.
• W126987811 hasConceptScore W126987811C105580179 @default.
• W126987811 hasConceptScore W126987811C105702510 @default.

• next