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- W127003677 abstract "Publisher Summary This chapter discusses transition state analogs as antimetabolites. Transition state analogs are enzyme inhibitors that are designed to exploit and make manifest the special interactions that distinguish the substrate in the transition state from the substrate in the ground state. It is evidently essential for catalysis that the enzyme's affinity for the substrate grows tighter as the transition state is approached, diminishing later as products are formed and released. Factors that contribute to their affinity for enzymes and to the efficiency of the catalytic process itself are matters of continuing interest. These factors can be evaluated through kinetic and structural studies of enzyme complexes with transition state analogs. In due course, these studies can be expected to reveal the form of the bound inhibitor to suggest the nature of any structural reorganization of the active site that accompanies substrate transformation and to indicate likely directions for further improvement in inhibitor design." @default.
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- W127003677 date "1979-01-01" @default.
- W127003677 modified "2023-10-16" @default.
- W127003677 title "TRANSITION STATE ANALOGS AS ANTIMETABOLITES" @default.
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- W127003677 doi "https://doi.org/10.1016/b978-0-08-024384-9.50016-6" @default.
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