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- W127092285 abstract "Imaging techniques, which allow for the mapping of metabolic and hemodynamic changes, have been widely applied to study the consequences of seizures and epilepsy in the adult and immature brain. These studies show that glucose demand is very large during prolonged periods of seizure discharge, while rates of cerebral blood flow remain adjusted to metabolic demands only for short durations. The ensuing mismatch between flow and metabolism leads to relative hypoperfusion and correlates regionally with neuronal death in the adult but not immature brain. This difference is consistent with the known resistance of the immature brain to seizure-induced neuronal damage. In some types of seizures in the immature animal, there is a redistribution of regional metabolic rates in favor of posterior regions mediating cardiorespiratory vital functions. Finally, these very useful imaging mapping tools could be successfully used to delineate the specific role of specific cerebral structures at various steps of the epileptogenic process." @default.
- W127092285 created "2016-06-24" @default.
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- W127092285 date "2009-01-01" @default.
- W127092285 modified "2023-09-25" @default.
- W127092285 title "METABOLIC CHANGES | Seizure-Induced Metabolic and Hemodynamic Changes in the Immature Brain" @default.
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- W127092285 doi "https://doi.org/10.1016/b978-012373961-2.00137-5" @default.
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