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• W127187645 abstract "This chapter describes the regulation of eukaryotic protein chain initiation by protein kinases and heme. Reticulocyte lysates provide a model system for studies on the regulation of protein synthesis owing to several unique properties. They include an efficient rate of initiation, the extensive synthesis of one major protein species, and the complete dependence of protein synthesis on exogenous hemin. In the presence of optimal concentrations of added hemin, protein synthesis proceeds at linear rates for prolonged periods. During the period of linear synthesis, the polyribosomes are maintained, and initiation factors are utilized catalytically. In efficient lysates, the rate of globin synthesis is comparable to the in vivo rate. In the absence of added hemin, protein synthesis proceeds at the control rate for several minutes, and then declines abruptly yielding characteristic biphasic kinetics of inhibition. The studies have established that the inhibition is mediated through a translational inhibitor which is rapidly activated in the absence of heme." @default.
• W127187645 created "2016-06-24" @default.
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• W127187645 date "1978-01-01" @default.
• W127187645 modified "2023-09-26" @default.
• W127187645 title "REGULATION OF EUKARYOTIC PROTEIN CHAIN INITIATION BY PROTEIN KINASES AND HEME" @default.
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• W127187645 doi "https://doi.org/10.1016/b978-0-08-022624-8.50009-0" @default.
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