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- W1274321 endingPage "91" @default.
- W1274321 startingPage "71" @default.
- W1274321 abstract "Obstructive sleep apnea (OSA) associated with recurrent apnea is one of the most commonly encountered breathing disorders in adult humans. Patients with OSA are prone to develop hypertension and cardiovascular diseases. Despite its adverse clinical consequences, the mechanism(s) by which recurrent apneas lead to cardiovascular abnormalities is poorly understood. OSA causes periodic decreases in arterial blood O2 or intermittent hypoxia (IH). Available evidence suggests that exposing experimental animals to IH during sleep is sufficient to induce cardiovascular abnormalities similar to those seen in OSA patients. A majority of cross-sectional and prospective studies show that patients with severe OSA exhibit oxidative stress compared to healthy humans. Studies in experimental animals provide evidence for IH-induced ROS generation mediating cardiovascular dysfunction. IH-evoked ROS generation seems to involve activation of NADPH oxidase, inhibition of mitochondrial complex I, and downregulation of antioxidant enzymes. Recent studies have identified hypoxia-inducible factor-1 and 2 as major molecular determinants for sustained oxidative stress elicited by IH. Continuous positive airway pressure treatment, which reduces oxidative stress, appears to be effective in attenuating cardiovascular dysfunction in a subset of OSA patients." @default.
- W1274321 created "2016-06-24" @default.
- W1274321 creator A5010883631 @default.
- W1274321 creator A5031114280 @default.
- W1274321 creator A5064414704 @default.
- W1274321 date "2014-01-01" @default.
- W1274321 modified "2023-10-09" @default.
- W1274321 title "ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea" @default.
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