Matches in SemOpenAlex for { <https://semopenalex.org/work/W127461514> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W127461514 endingPage "4" @default.
- W127461514 startingPage "60" @default.
- W127461514 abstract "Since 1963 there have been 266 patients with cancer of the uterine fundus at the Medical University of South Carolina. Progestational agents were used to treat 54 but 10 received the drugs for less than 1 month. This report relates to the remaining 44. 34 were treated with Depo-Provera (medroxyprogesterone acetate), 9 with Colprone (megestrone acetate), and 1 with Megace (megestrol acetate). Of the 34 patients treated with Depo-Provera 13 showed regression of the tumor; 3 of the 9 treated with Colprone showed regression. In an additional 11 (25%) of cases growth of the tumors was arrested. 7 of these were later found to have abdominal metastases; however, 3 were free of symptoms for over 43 months. A patient on Depo-Provera with lung metastases had recurrence after 62 months when treatment was reduced to every other week but when Colprone was then given, regression again occurred and has continued for almost 10 years. Another patient not responding to Depo-Provera did respond to Colprone. Average duration of regression was 27.7 months, of survival 31.1 months. Arrest of growth was 25 months in some; survival averaged 23.4 months. (The 1 Megace case was in this group.)y Those having progression of tumors lived an average of 9 months with the longest survival 24 months. Of the responders 8 lived from 44 to 111 months and 5 remain alive, 4 now showing no evidence of the cancer. Tumors with well-differentiated, slow-growing lesions were most likely to respond. Site of recurrence did not seem to influence the response. No contraindications were found to use of progestational agents in this type of cancer. Local reactions to the injections were few. Subjective response was frequent even though progression was taking place." @default.
- W127461514 created "2016-06-24" @default.
- W127461514 creator A5016105375 @default.
- W127461514 creator A5044065832 @default.
- W127461514 date "1974-07-01" @default.
- W127461514 modified "2023-09-23" @default.
- W127461514 title "Use of progestational agents in endometrial adenocarcinoma." @default.
- W127461514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4834800" @default.
- W127461514 hasPublicationYear "1974" @default.
- W127461514 type Work @default.
- W127461514 sameAs 127461514 @default.
- W127461514 citedByCount "12" @default.
- W127461514 countsByYear W1274615142022 @default.
- W127461514 crossrefType "journal-article" @default.
- W127461514 hasAuthorship W127461514A5016105375 @default.
- W127461514 hasAuthorship W127461514A5044065832 @default.
- W127461514 hasConcept C121608353 @default.
- W127461514 hasConcept C126322002 @default.
- W127461514 hasConcept C2775934596 @default.
- W127461514 hasConcept C2776306185 @default.
- W127461514 hasConcept C2777164284 @default.
- W127461514 hasConcept C2780723184 @default.
- W127461514 hasConcept C2781182431 @default.
- W127461514 hasConcept C29456083 @default.
- W127461514 hasConcept C71924100 @default.
- W127461514 hasConceptScore W127461514C121608353 @default.
- W127461514 hasConceptScore W127461514C126322002 @default.
- W127461514 hasConceptScore W127461514C2775934596 @default.
- W127461514 hasConceptScore W127461514C2776306185 @default.
- W127461514 hasConceptScore W127461514C2777164284 @default.
- W127461514 hasConceptScore W127461514C2780723184 @default.
- W127461514 hasConceptScore W127461514C2781182431 @default.
- W127461514 hasConceptScore W127461514C29456083 @default.
- W127461514 hasConceptScore W127461514C71924100 @default.
- W127461514 hasIssue "1" @default.
- W127461514 hasLocation W1274615141 @default.
- W127461514 hasOpenAccess W127461514 @default.
- W127461514 hasPrimaryLocation W1274615141 @default.
- W127461514 hasRelatedWork W134808148 @default.
- W127461514 hasRelatedWork W1968678237 @default.
- W127461514 hasRelatedWork W2006118224 @default.
- W127461514 hasRelatedWork W2047502119 @default.
- W127461514 hasRelatedWork W2053372893 @default.
- W127461514 hasRelatedWork W2072705726 @default.
- W127461514 hasRelatedWork W2112317094 @default.
- W127461514 hasRelatedWork W2113695553 @default.
- W127461514 hasRelatedWork W2323764327 @default.
- W127461514 hasRelatedWork W2325761956 @default.
- W127461514 hasVolume "44" @default.
- W127461514 isParatext "false" @default.
- W127461514 isRetracted "false" @default.
- W127461514 magId "127461514" @default.
- W127461514 workType "article" @default.