FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W127580824> ?p ?o ?g. }

• W127580824 endingPage "967" @default.
• W127580824 startingPage "958" @default.
• W127580824 abstract "The use of aprotinin to reduce blood loss after cardiopulmonary bypass is under debate. Concern has been raised about the renal effects of aprotinin. We administered a mean aprotinin dose of 4.2 × 106 kallikrein-inhibiting units to 13 patients with coronary disease undergoing cardiopulmonary bypass for 74 ± 5 minutes (mean ± standard error of the mean); 13 comparable patients having cardiopulmonary bypass served as control subjects, and all were studied postoperatively for 24 hours. Aprotinin reduced postoperative blood loss by 50% (p = 0.0082). Two of the 13 patients who received aprotinin needed one red cell unit each versus a total of 18 units in eight of 13 control patients (p = 0.0096). Blood pressure, hemoglobin value and serum protein concentration were higher after operation in the aprotinin group (p < 0.05 to p < 0.01). Platelet counts did not differ, but plasma thromboxane was lower in aprotinin recipients (p < 0.001). In control patients fibrinogen degradation products (D dimer) doubled, and α2-antiplasmin activity was halved during and after cardiopulmonary bypass (p < 0.01 to p < 0.001), whereas aprotinin patients showed no changes. The complement breakdown products C4a, C3a, and C3dg as well as C9 neoantigen increased from prebypass baseline in both groups (p < 0.001); the increment of C3a and C3dg was greater in the aprotinin than in the control patients (p < 0.001). Serum electrolytes, osmolality, and creatinine remained normal in both groups of patients. Creatinine clearance was normal or above normal and virtually identical in both groups. Osmolar clearance and fractional sodium excretion were higher in the aprotinin group than in the control group shortly after cardiopulmonary bypass (p < 0.05 to p < 0.01); renal function was unremarkable the next morning. No adverse clinical effects attributable to aprotinin were seen. In summary, aprotinin offers advantages for cardiopulmonary bypass." @default.
• W127580824 created "2016-06-24" @default.
• W127580824 creator A5004237078 @default.
• W127580824 creator A5006284944 @default.
• W127580824 creator A5026292383 @default.
• W127580824 creator A5028394728 @default.
• W127580824 creator A5056200970 @default.
• W127580824 creator A5077475178 @default.
• W127580824 date "1991-06-01" @default.
• W127580824 modified "2023-10-16" @default.
• W127580824 title "Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass" @default.
• W127580824 cites W156787248 @default.
• W127580824 cites W1964230120 @default.
• W127580824 cites W1969656282 @default.
• W127580824 cites W1978039741 @default.
• W127580824 cites W1978941357 @default.
• W127580824 cites W1987433905 @default.
• W127580824 cites W1997068213 @default.
• W127580824 cites W1998421638 @default.
• W127580824 cites W1999386605 @default.
• W127580824 cites W2009699612 @default.
• W127580824 cites W2017118779 @default.
• W127580824 cites W2034822526 @default.
• W127580824 cites W2057646315 @default.
• W127580824 cites W2060723157 @default.
• W127580824 cites W2070586531 @default.
• W127580824 cites W2121216366 @default.
• W127580824 cites W2156910916 @default.
• W127580824 cites W2157217694 @default.
• W127580824 cites W2253816243 @default.
• W127580824 cites W2278781543 @default.
• W127580824 cites W2336104980 @default.
• W127580824 cites W2341772947 @default.
• W127580824 cites W2404697974 @default.
• W127580824 cites W2406370786 @default.
• W127580824 cites W2410245757 @default.
• W127580824 cites W2412218990 @default.
• W127580824 doi "https://doi.org/10.1016/s0022-5223(19)36611-5" @default.
• W127580824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1710008" @default.
• W127580824 hasPublicationYear "1991" @default.
• W127580824 type Work @default.
• W127580824 sameAs 127580824 @default.
• W127580824 citedByCount "234" @default.
• W127580824 countsByYear W1275808242013 @default.
• W127580824 countsByYear W1275808242015 @default.
• W127580824 countsByYear W1275808242016 @default.
• W127580824 crossrefType "journal-article" @default.
• W127580824 hasAuthorship W127580824A5004237078 @default.
• W127580824 hasAuthorship W127580824A5006284944 @default.
• W127580824 hasAuthorship W127580824A5026292383 @default.
• W127580824 hasAuthorship W127580824A5028394728 @default.
• W127580824 hasAuthorship W127580824A5056200970 @default.
• W127580824 hasAuthorship W127580824A5077475178 @default.
• W127580824 hasBestOaLocation W1275808241 @default.
• W127580824 hasConcept C126322002 @default.
• W127580824 hasConcept C126894567 @default.
• W127580824 hasConcept C159641895 @default.
• W127580824 hasConcept C164705383 @default.
• W127580824 hasConcept C2776825266 @default.
• W127580824 hasConcept C2778881276 @default.
• W127580824 hasConcept C2780306776 @default.
• W127580824 hasConcept C2780799893 @default.
• W127580824 hasConcept C42219234 @default.
• W127580824 hasConcept C71924100 @default.
• W127580824 hasConcept C89560881 @default.
• W127580824 hasConceptScore W127580824C126322002 @default.
• W127580824 hasConceptScore W127580824C126894567 @default.
• W127580824 hasConceptScore W127580824C159641895 @default.
• W127580824 hasConceptScore W127580824C164705383 @default.
• W127580824 hasConceptScore W127580824C2776825266 @default.
• W127580824 hasConceptScore W127580824C2778881276 @default.
• W127580824 hasConceptScore W127580824C2780306776 @default.
• W127580824 hasConceptScore W127580824C2780799893 @default.
• W127580824 hasConceptScore W127580824C42219234 @default.
• W127580824 hasConceptScore W127580824C71924100 @default.
• W127580824 hasConceptScore W127580824C89560881 @default.
• W127580824 hasIssue "6" @default.
• W127580824 hasLocation W1275808241 @default.
• W127580824 hasLocation W1275808242 @default.
• W127580824 hasOpenAccess W127580824 @default.
• W127580824 hasPrimaryLocation W1275808241 @default.
• W127580824 hasRelatedWork W1544023406 @default.
• W127580824 hasRelatedWork W1966157403 @default.
• W127580824 hasRelatedWork W1974378936 @default.
• W127580824 hasRelatedWork W2012627011 @default.
• W127580824 hasRelatedWork W2046899919 @default.
• W127580824 hasRelatedWork W2077677598 @default.
• W127580824 hasRelatedWork W2097837600 @default.
• W127580824 hasRelatedWork W2157571881 @default.
• W127580824 hasRelatedWork W393698729 @default.
• W127580824 hasRelatedWork W800937107 @default.
• W127580824 hasVolume "101" @default.
• W127580824 isParatext "false" @default.
• W127580824 isRetracted "false" @default.
• W127580824 magId "127580824" @default.
• W127580824 workType "article" @default.