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- W12760168 abstract "Hypothalamus liberates a substance into the hypophysial portal blood that stimulates the adrenocorticotrophic hormone (ACTH) activity of the pituitary. This chapter discusses the chemical and biological characterization of this corticotropin releasing factor (CRF). Several known naturally occurring substances including vasopressin, oxytocin, norepinephrine, epinephrine, and angiotensin II are found to stimulate ACTH secretion. Partially purified preparations of CRF stimulates the secretion of a number of peptides derived from the proopiomelanocortin (POMC) precursor—including the opioid peptide, β-endorphin. The chapter explains that CRF is likely to be distributed outside of the hypothalamus and possess extra hypophysiotropic actions. In vitro systems are vulnerable to non specific secretagogs in extracts including myelin basic protein, histones, potassium ion, and the components of various buffers and solvents. Ovine CRF is homologous with several known peptides including sauvagine and urotensin I. CRF also shows some homology with calmodulin and with angiotensinogen. The tetrapeptide Phe-His-Leu-Leu is common to both angiotensinogen and CRF and is the site in angiotensinogen of renin and converting enzyme cleavage. The chapter concludes with the evidence that supports CRF or a closely related peptide in the neuroregulation of the pituitary corticotropic cells." @default.
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- W12760168 date "1983-01-01" @default.
- W12760168 modified "2023-10-16" @default.
- W12760168 title "Chemical and Biological Characterization of Corticotropin Releasing Factor" @default.
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- W12760168 doi "https://doi.org/10.1016/b978-0-12-571139-5.50010-0" @default.
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