FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W127622958> ?p ?o ?g. }

• W127622958 abstract "Author(s): Agrawal, Madhav | Advisor(s): Seo, Youngho | Abstract: Introduction: Breast cancer is prevalent health issue in women. Currently PET scanning is used as a noninvasive means to provide physiological information the uptake of glucose and its metabolism. This is performed by using the 18F-FDG tracer, which is a glucose analog. Currently, in vitro experiments are executed to understand the metabolism and glucose uptake of breast cancer cell lines in order to develop novel therapeutics. However, the in vitro glucose uptake data on breast cancer cell lines contradicts our speculation of how the trend should look, which is based off our understanding of cell line's characteristics in human models. The aim of our study is to ensure if glucose uptake in vitro correlates with in vivo glucose uptake (FDG tracer). Methods: 7 breast cancer cell lines were bilaterally implanted with the same cell line in the mammary fat pad of immunodeficient mice (SCID and NSG). The mice were monitored for volume growth and were imaged by microPET/CT when the tumors reached about 200 mm3. The mice were injected with about 200 μCi/0.1 ml concentrations. Results and Discussions: Small correlation (R2 = 0.08394) was between the comparisons of glucose uptake in vitro and FDG uptake in vivo. Imaging was seen as inconsistent for two different cell lines. No correlation (R2 = 0.00666) was observed in the comparison between volume (in all instance) and their corresponding FDG uptake. Volume growth was an issue with all the animals and it is speculated that the implantation procedure is not optimal. Low correlation (R2 = 0.0352) is observed in the overall comparison between FDG uptakes and volume growth rate. A comparison was done to clarify if %ID/gmax can be used instead of SUVmax, which resulted in a strong correlation (as expected). Further studies are needed due to small sample size Conclusion: At the end of the study, it was observed that glucose uptake in vitro does not correlate with FDG uptake in vivo. This has a strong implication that in vitro studies for glucose uptake might not be translated to in vivo uptake." @default.
• W127622958 created "2016-06-24" @default.
• W127622958 creator A5063637719 @default.
• W127622958 date "2013-01-01" @default.
• W127622958 modified "2023-09-26" @default.
• W127622958 title "18f-FDG PET/CT to measure glucose metabolism of various breast cancer cell lines in vivo" @default.
• W127622958 hasPublicationYear "2013" @default.
• W127622958 type Work @default.
• W127622958 sameAs 127622958 @default.
• W127622958 citedByCount "0" @default.
• W127622958 crossrefType "journal-article" @default.
• W127622958 hasAuthorship W127622958A5063637719 @default.
• W127622958 hasConcept C121608353 @default.
• W127622958 hasConcept C126322002 @default.
• W127622958 hasConcept C134018914 @default.
• W127622958 hasConcept C150903083 @default.
• W127622958 hasConcept C17093226 @default.
• W127622958 hasConcept C185592680 @default.
• W127622958 hasConcept C202751555 @default.
• W127622958 hasConcept C207001950 @default.
• W127622958 hasConcept C2775842073 @default.
• W127622958 hasConcept C2777866211 @default.
• W127622958 hasConcept C2779306644 @default.
• W127622958 hasConcept C2989005 @default.
• W127622958 hasConcept C2994372470 @default.
• W127622958 hasConcept C502942594 @default.
• W127622958 hasConcept C530470458 @default.
• W127622958 hasConcept C54355233 @default.
• W127622958 hasConcept C55493867 @default.
• W127622958 hasConcept C62231903 @default.
• W127622958 hasConcept C71924100 @default.
• W127622958 hasConcept C81885089 @default.
• W127622958 hasConcept C86803240 @default.
• W127622958 hasConcept C96232424 @default.
• W127622958 hasConceptScore W127622958C121608353 @default.
• W127622958 hasConceptScore W127622958C126322002 @default.
• W127622958 hasConceptScore W127622958C134018914 @default.
• W127622958 hasConceptScore W127622958C150903083 @default.
• W127622958 hasConceptScore W127622958C17093226 @default.
• W127622958 hasConceptScore W127622958C185592680 @default.
• W127622958 hasConceptScore W127622958C202751555 @default.
• W127622958 hasConceptScore W127622958C207001950 @default.
• W127622958 hasConceptScore W127622958C2775842073 @default.
• W127622958 hasConceptScore W127622958C2777866211 @default.
• W127622958 hasConceptScore W127622958C2779306644 @default.
• W127622958 hasConceptScore W127622958C2989005 @default.
• W127622958 hasConceptScore W127622958C2994372470 @default.
• W127622958 hasConceptScore W127622958C502942594 @default.
• W127622958 hasConceptScore W127622958C530470458 @default.
• W127622958 hasConceptScore W127622958C54355233 @default.
• W127622958 hasConceptScore W127622958C55493867 @default.
• W127622958 hasConceptScore W127622958C62231903 @default.
• W127622958 hasConceptScore W127622958C71924100 @default.
• W127622958 hasConceptScore W127622958C81885089 @default.
• W127622958 hasConceptScore W127622958C86803240 @default.
• W127622958 hasConceptScore W127622958C96232424 @default.
• W127622958 hasLocation W1276229581 @default.
• W127622958 hasOpenAccess W127622958 @default.
• W127622958 hasPrimaryLocation W1276229581 @default.
• W127622958 hasRelatedWork W1762225077 @default.
• W127622958 hasRelatedWork W1962363169 @default.
• W127622958 hasRelatedWork W1985029317 @default.
• W127622958 hasRelatedWork W1997910821 @default.
• W127622958 hasRelatedWork W2000958299 @default.
• W127622958 hasRelatedWork W2017531551 @default.
• W127622958 hasRelatedWork W2027448381 @default.
• W127622958 hasRelatedWork W2027717331 @default.
• W127622958 hasRelatedWork W2119360608 @default.
• W127622958 hasRelatedWork W2125218519 @default.
• W127622958 hasRelatedWork W2144603209 @default.
• W127622958 hasRelatedWork W2147555534 @default.
• W127622958 hasRelatedWork W2153326904 @default.
• W127622958 hasRelatedWork W2372654543 @default.
• W127622958 hasRelatedWork W2553156320 @default.
• W127622958 hasRelatedWork W2907484358 @default.
• W127622958 hasRelatedWork W3006912845 @default.
• W127622958 hasRelatedWork W3160040105 @default.
• W127622958 hasRelatedWork W2185579526 @default.
• W127622958 hasRelatedWork W2527340402 @default.
• W127622958 isParatext "false" @default.
• W127622958 isRetracted "false" @default.
• W127622958 magId "127622958" @default.
• W127622958 workType "article" @default.