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- W127639384 abstract "The suitability of a mesoporous silicate matrix as a drug-delivery system has been evaluated using different nonsteroid anti-inflammatory agents as model drugs. This type of matrix can trap the bioactive agents by a soaking procedure and then release them in conditions mimicking the biological fluids. The high affinity of these matrices for water makes them potentially biocompatible. A matrix impregnated with diflunisal can offer a good potential as a system for the controlled drug release. In fact, only 20% of the drug is released at the gastric level allowing, in this way, the reduction of side effects related to the oral administration of nonsteroidal anti-inflammatory agents and the release of the most part of drug in the intestinal duct. In this regard, hydroxyl population that is responsible for the interaction between the drug and the silicate surface depends on the activation method." @default.
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- W127639384 date "2002-01-01" @default.
- W127639384 modified "2023-10-18" @default.
- W127639384 title "Mesoporous silicate as matrix for drug delivery systems of non-steroidal antinflammatory drugs" @default.
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- W127639384 doi "https://doi.org/10.1016/s0167-2991(02)80276-2" @default.
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