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- W127691036 abstract "Bone marrow cellularity, hematopoietic progenitor cells and immune alterations were evaluated in mice following short term adult exposures to non-ulcerogenic levels of indomethacin. Body and organ weights showed no significant changes with the exception of the spleen where a dose dependent weight increase was noted. Bone marrow cellularity and pleuripotent hemopoietic stem cells (CFU-S) were unaltered while granulocyte-macrophage progenitors (CFU-GM) and splenic erythropoiesis were increased. Indomethacin exposure caused increased macrophage function as evidenced by enhanced phagocytosis. Lymphoproliferative response of splenocytes to T-cell mitogens was depressed while B-cell mitogenic response was not affected. These results indicate that indomethacin affects selective components of the immune and hemopoietic cells at dose levels that cause no other significant pathological alterations." @default.
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- W127691036 date "1982-02-01" @default.
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- W127691036 title "Effect of indomethacin on the bone marrow and immune system of the mouse." @default.
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