Matches in SemOpenAlex for { <https://semopenalex.org/work/W127780887> ?p ?o ?g. }
- W127780887 endingPage "373" @default.
- W127780887 startingPage "353" @default.
- W127780887 abstract "Diabetic retinopathy (DR) is a major cause of blindness in the United States and other industrialized countries. Retinal neovascularization is the hallmark of the proliferative stage of diabetic retinopathy and is a major cause of vision loss in diabetes. This chapter discusses our current knowledge regarding the mechanisms underlying retinal neovascularization in diabetic retinopathy, with a focus on the critical role played by vascular endothelial growth factor (VEGF). The current understanding of the stages of neovascularization is reviewed, beginning with the ischemic/hypoxic stimulus that is thought to play a critical role in the transition from nonproliferative to proliferative diabetic retinopathy. The evidence supporting the importance of VEGF in diabetic retinopathy is presented, including clinical, preclinical, and basic research studies. Furthermore, the regulation of VEGF expression in the retina as well as its actions at the cellular and molecular level is discussed in detail. In the light of VEGF's pathophysiologic importance in DR, the development of therapeutics targeting VEGF and its downstream actions is a promising approach for current and future treatment of proliferative diabetic retinopathy." @default.
- W127780887 created "2016-06-24" @default.
- W127780887 creator A5016107456 @default.
- W127780887 date "2008-01-01" @default.
- W127780887 modified "2023-10-16" @default.
- W127780887 title "Retinal Neovascularization and the Role of VEGF" @default.
- W127780887 cites W1125525217 @default.
- W127780887 cites W1214250537 @default.
- W127780887 cites W1489873347 @default.
- W127780887 cites W1537712767 @default.
- W127780887 cites W1543694381 @default.
- W127780887 cites W1562028693 @default.
- W127780887 cites W1587020653 @default.
- W127780887 cites W1625720053 @default.
- W127780887 cites W187440223 @default.
- W127780887 cites W1875554126 @default.
- W127780887 cites W1894493322 @default.
- W127780887 cites W1962154683 @default.
- W127780887 cites W1967004211 @default.
- W127780887 cites W1969328947 @default.
- W127780887 cites W1970494874 @default.
- W127780887 cites W1972979395 @default.
- W127780887 cites W1974568895 @default.
- W127780887 cites W1977532338 @default.
- W127780887 cites W1979149433 @default.
- W127780887 cites W1980969801 @default.
- W127780887 cites W1982265214 @default.
- W127780887 cites W1982831550 @default.
- W127780887 cites W1983345433 @default.
- W127780887 cites W1983763042 @default.
- W127780887 cites W1985804036 @default.
- W127780887 cites W1985965517 @default.
- W127780887 cites W1988143227 @default.
- W127780887 cites W1992633678 @default.
- W127780887 cites W1999961827 @default.
- W127780887 cites W2000292756 @default.
- W127780887 cites W2000663727 @default.
- W127780887 cites W2003996544 @default.
- W127780887 cites W2004643661 @default.
- W127780887 cites W2006480537 @default.
- W127780887 cites W2007057348 @default.
- W127780887 cites W2009812837 @default.
- W127780887 cites W2013038209 @default.
- W127780887 cites W2013932535 @default.
- W127780887 cites W2014148719 @default.
- W127780887 cites W2015344488 @default.
- W127780887 cites W2017962415 @default.
- W127780887 cites W2018146706 @default.
- W127780887 cites W2018586410 @default.
- W127780887 cites W2023353015 @default.
- W127780887 cites W2025933554 @default.
- W127780887 cites W2029763523 @default.
- W127780887 cites W2034393061 @default.
- W127780887 cites W2037623358 @default.
- W127780887 cites W2038281158 @default.
- W127780887 cites W2043863730 @default.
- W127780887 cites W2045247659 @default.
- W127780887 cites W2048741717 @default.
- W127780887 cites W2049569341 @default.
- W127780887 cites W2053224964 @default.
- W127780887 cites W2053272214 @default.
- W127780887 cites W2054353907 @default.
- W127780887 cites W2055696255 @default.
- W127780887 cites W2057100984 @default.
- W127780887 cites W2059775221 @default.
- W127780887 cites W2059948410 @default.
- W127780887 cites W2062594120 @default.
- W127780887 cites W2063709616 @default.
- W127780887 cites W2065550467 @default.
- W127780887 cites W2067817921 @default.
- W127780887 cites W2075086348 @default.
- W127780887 cites W2075553837 @default.
- W127780887 cites W2085106372 @default.
- W127780887 cites W2087409531 @default.
- W127780887 cites W2091534585 @default.
- W127780887 cites W2093498435 @default.
- W127780887 cites W2107572492 @default.
- W127780887 cites W2114098415 @default.
- W127780887 cites W2125014313 @default.
- W127780887 cites W2131515450 @default.
- W127780887 cites W2137893922 @default.
- W127780887 cites W2138412834 @default.
- W127780887 cites W2143944465 @default.
- W127780887 cites W2146587653 @default.
- W127780887 cites W2153259848 @default.
- W127780887 cites W2156271388 @default.
- W127780887 cites W2163069245 @default.
- W127780887 cites W2163252729 @default.
- W127780887 cites W2164738538 @default.
- W127780887 cites W2164923772 @default.
- W127780887 cites W2324588265 @default.
- W127780887 cites W4212945288 @default.
- W127780887 cites W4244033321 @default.
- W127780887 cites W4245192604 @default.
- W127780887 cites W4246641905 @default.
- W127780887 doi "https://doi.org/10.1007/978-1-59745-563-3_15" @default.
- W127780887 hasPublicationYear "2008" @default.
- W127780887 type Work @default.