FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1279083794> ?p ?o ?g. }

• W1279083794 endingPage "197" @default.
• W1279083794 startingPage "187" @default.
• W1279083794 abstract "Background: Metronomic chemotherapy involves frequent, regular administration of cytotoxic drugs at nontoxic doses, usually without prolonged breaks. We investigated the therapeutic efficacies of metronomic S-1, an oral 5-fluorouracil prodrug, and vandetanib, an epidermal growth factor receptor and vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor, in models of hepatocellular carcinoma (HCC). Methods: We compared anti-HCC effects and toxicity in the six treatment groups: control (untreated), maximum tolerated dose (MTD) S-1, metronomic S-1, vandetanib, MTD S-1 with vandetanib, and metronomic S-1 with vandetanib. Tumor microvessel density (MVD) and tumor apoptosis were evaluated by immunohistochemistry. The expression of VEGF and thrombospondin-1, an endogenous inhibitor of angiogenesis, was analyzed by Western blot. Results: Metronomic S-1 significantly inhibited tumor growth, which was enhanced by combination with vandetanib. With respect to toxicities, MTD S-1 caused severe body weight loss and myelosuppression, whereas metronomic S-1 did not cause any overt toxicities. Moreover, metronomic S-1 or metronomic S-1 with vandetanib prolonged survival, the latter treatment providing the greatest benefit. Metronomic S-1 and metronomic S-1 with vandetanib decreased MVDs and increased apoptosis in tumor tissues. The expression of VEGF in tumor tissues was upregulated by vandetanib and metronomic S-1 with vandetanib, whereas the expression of thrombospondin-1 was upregulated by metronomic S-1 and metronomic S-1 with vandetanib. Conclusion: Metronomic S-1 with an antiangiogenic agent seems to be an effective and safe therapeutic strategy for HCC." @default.
• W1279083794 created "2016-06-24" @default.
• W1279083794 creator A5010799165 @default.
• W1279083794 creator A5013194037 @default.
• W1279083794 creator A5020635106 @default.
• W1279083794 creator A5021562894 @default.
• W1279083794 creator A5021957719 @default.
• W1279083794 creator A5032328519 @default.
• W1279083794 creator A5036686914 @default.
• W1279083794 creator A5047725445 @default.
• W1279083794 creator A5049570653 @default.
• W1279083794 creator A5058270687 @default.
• W1279083794 creator A5060744842 @default.
• W1279083794 creator A5074219274 @default.
• W1279083794 creator A5084794851 @default.
• W1279083794 creator A5084839932 @default.
• W1279083794 date "2011-03-01" @default.
• W1279083794 modified "2023-09-26" @default.
• W1279083794 title "Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma" @default.
• W1279083794 cites W1595263809 @default.
• W1279083794 cites W1897802257 @default.
• W1279083794 cites W1929987490 @default.
• W1279083794 cites W1967600348 @default.
• W1279083794 cites W1971837077 @default.
• W1279083794 cites W1973091654 @default.
• W1279083794 cites W1977127004 @default.
• W1279083794 cites W2005627135 @default.
• W1279083794 cites W2017352677 @default.
• W1279083794 cites W2029883816 @default.
• W1279083794 cites W2032231188 @default.
• W1279083794 cites W2034548257 @default.
• W1279083794 cites W2075549113 @default.
• W1279083794 cites W2090806526 @default.
• W1279083794 cites W2098321535 @default.
• W1279083794 cites W2102392974 @default.
• W1279083794 cites W2107175347 @default.
• W1279083794 cites W2111489144 @default.
• W1279083794 cites W2118559000 @default.
• W1279083794 cites W2130349349 @default.
• W1279083794 cites W2131798870 @default.
• W1279083794 cites W2153935627 @default.
• W1279083794 cites W2157628203 @default.
• W1279083794 cites W2163453798 @default.
• W1279083794 cites W2169965478 @default.
• W1279083794 cites W2171075804 @default.
• W1279083794 doi "https://doi.org/10.1593/neo.101186" @default.
• W1279083794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3050862" @default.
• W1279083794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21390182" @default.
• W1279083794 hasPublicationYear "2011" @default.
• W1279083794 type Work @default.
• W1279083794 sameAs 1279083794 @default.
• W1279083794 citedByCount "30" @default.
• W1279083794 countsByYear W12790837942012 @default.
• W1279083794 countsByYear W12790837942013 @default.
• W1279083794 countsByYear W12790837942014 @default.
• W1279083794 countsByYear W12790837942015 @default.
• W1279083794 countsByYear W12790837942016 @default.
• W1279083794 countsByYear W12790837942017 @default.
• W1279083794 countsByYear W12790837942018 @default.
• W1279083794 countsByYear W12790837942019 @default.
• W1279083794 countsByYear W12790837942021 @default.
• W1279083794 countsByYear W12790837942022 @default.
• W1279083794 crossrefType "journal-article" @default.
• W1279083794 hasAuthorship W1279083794A5010799165 @default.
• W1279083794 hasAuthorship W1279083794A5013194037 @default.
• W1279083794 hasAuthorship W1279083794A5020635106 @default.
• W1279083794 hasAuthorship W1279083794A5021562894 @default.
• W1279083794 hasAuthorship W1279083794A5021957719 @default.
• W1279083794 hasAuthorship W1279083794A5032328519 @default.
• W1279083794 hasAuthorship W1279083794A5036686914 @default.
• W1279083794 hasAuthorship W1279083794A5047725445 @default.
• W1279083794 hasAuthorship W1279083794A5049570653 @default.
• W1279083794 hasAuthorship W1279083794A5058270687 @default.
• W1279083794 hasAuthorship W1279083794A5060744842 @default.
• W1279083794 hasAuthorship W1279083794A5074219274 @default.
• W1279083794 hasAuthorship W1279083794A5084794851 @default.
• W1279083794 hasAuthorship W1279083794A5084839932 @default.
• W1279083794 hasBestOaLocation W12790837941 @default.
• W1279083794 hasConcept C121608353 @default.
• W1279083794 hasConcept C126322002 @default.
• W1279083794 hasConcept C143998085 @default.
• W1279083794 hasConcept C167734588 @default.
• W1279083794 hasConcept C2776056115 @default.
• W1279083794 hasConcept C2777025900 @default.
• W1279083794 hasConcept C2778019345 @default.
• W1279083794 hasConcept C2778695046 @default.
• W1279083794 hasConcept C2778820342 @default.
• W1279083794 hasConcept C2780333294 @default.
• W1279083794 hasConcept C2780394083 @default.
• W1279083794 hasConcept C502942594 @default.
• W1279083794 hasConcept C71924100 @default.
• W1279083794 hasConcept C98274493 @default.
• W1279083794 hasConceptScore W1279083794C121608353 @default.
• W1279083794 hasConceptScore W1279083794C126322002 @default.
• W1279083794 hasConceptScore W1279083794C143998085 @default.
• W1279083794 hasConceptScore W1279083794C167734588 @default.
• W1279083794 hasConceptScore W1279083794C2776056115 @default.
• W1279083794 hasConceptScore W1279083794C2777025900 @default.

• next