Matches in SemOpenAlex for { <https://semopenalex.org/work/W1279103634> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1279103634 endingPage "394" @default.
- W1279103634 startingPage "389" @default.
- W1279103634 abstract "In India, Vatari Guggulu has been traditionally used in the Ayurvedic system of medicine to treat rheumatoid arthritis (RA). The current study was undertaken to evaluate anti-arthritic activity of alcoholic extract of Vatari Guggulu in rats. Arthritis was induced by administration of formaldehyde (2%v/v) or Complete Freund's Adjuvant (CFA) into the sub-plantar surface of left hind paw of the animals. The extract was administered to the rats by oral gavages in different doses. Joint swelling was measured in formaldehyde induced arthritis. Various physical, biochemical and histopathological parameters were determined in CFA induced arthritis. Vatari Guggulu extract (VGE) produced significant (P < 0.05) inhibition of joint swelling in both formaldehyde and CFA induced arthritis. The treatment also brought to normalcy the increased white blood cell (WBC) count, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), cholesterol, triglycerides and LDL with an enhancement of haemoglobin (Hb) levels and red blood cell (RBC) count. These effects were found to be dose dependent. These effects were comparable with standard drug indomethacin. Histo-pathological studies of the ankles of VGE treated animals exhibited significant improvements. VGE did not show any toxic symptoms even at a dose of 2000 mg/kg in acute toxicity studies on rats. Thus, Vatari Guggulu, a classical Ayurvedic formulation of the Indian System of Medicine, exhibited significant anti-arthritic activity in formaldehyde and CFA induced arthritis in rats. This study corroborates the claims of Ayurveda on Vatari Guggulu." @default.
- W1279103634 created "2016-06-24" @default.
- W1279103634 creator A5028869353 @default.
- W1279103634 creator A5052901017 @default.
- W1279103634 date "2016-10-01" @default.
- W1279103634 modified "2023-10-14" @default.
- W1279103634 title "Anti-arthritic activity of a classical Ayurvedic formulation Vatari Guggulu in rats" @default.
- W1279103634 cites W138815630 @default.
- W1279103634 cites W1970974410 @default.
- W1279103634 cites W1973624063 @default.
- W1279103634 cites W1988664219 @default.
- W1279103634 cites W1990131976 @default.
- W1279103634 cites W1997208118 @default.
- W1279103634 cites W2010587126 @default.
- W1279103634 cites W2021363185 @default.
- W1279103634 cites W2055406349 @default.
- W1279103634 cites W2075657946 @default.
- W1279103634 cites W2078775197 @default.
- W1279103634 cites W2123200029 @default.
- W1279103634 cites W2129612306 @default.
- W1279103634 cites W2137499656 @default.
- W1279103634 cites W2139713040 @default.
- W1279103634 cites W2261130562 @default.
- W1279103634 cites W2588701926 @default.
- W1279103634 cites W60457073 @default.
- W1279103634 doi "https://doi.org/10.1016/j.jtcme.2015.08.007" @default.
- W1279103634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5067862" @default.
- W1279103634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27774424" @default.
- W1279103634 hasPublicationYear "2016" @default.
- W1279103634 type Work @default.
- W1279103634 sameAs 1279103634 @default.
- W1279103634 citedByCount "17" @default.
- W1279103634 countsByYear W12791036342018 @default.
- W1279103634 countsByYear W12791036342019 @default.
- W1279103634 countsByYear W12791036342020 @default.
- W1279103634 countsByYear W12791036342021 @default.
- W1279103634 countsByYear W12791036342022 @default.
- W1279103634 countsByYear W12791036342023 @default.
- W1279103634 crossrefType "journal-article" @default.
- W1279103634 hasAuthorship W1279103634A5028869353 @default.
- W1279103634 hasAuthorship W1279103634A5052901017 @default.
- W1279103634 hasBestOaLocation W12791036341 @default.
- W1279103634 hasConcept C126322002 @default.
- W1279103634 hasConcept C2776232647 @default.
- W1279103634 hasConcept C2777077863 @default.
- W1279103634 hasConcept C2777575956 @default.
- W1279103634 hasConcept C2778143017 @default.
- W1279103634 hasConcept C2778488018 @default.
- W1279103634 hasConcept C556039675 @default.
- W1279103634 hasConcept C71924100 @default.
- W1279103634 hasConcept C98274493 @default.
- W1279103634 hasConceptScore W1279103634C126322002 @default.
- W1279103634 hasConceptScore W1279103634C2776232647 @default.
- W1279103634 hasConceptScore W1279103634C2777077863 @default.
- W1279103634 hasConceptScore W1279103634C2777575956 @default.
- W1279103634 hasConceptScore W1279103634C2778143017 @default.
- W1279103634 hasConceptScore W1279103634C2778488018 @default.
- W1279103634 hasConceptScore W1279103634C556039675 @default.
- W1279103634 hasConceptScore W1279103634C71924100 @default.
- W1279103634 hasConceptScore W1279103634C98274493 @default.
- W1279103634 hasIssue "4" @default.
- W1279103634 hasLocation W12791036341 @default.
- W1279103634 hasLocation W12791036342 @default.
- W1279103634 hasLocation W12791036343 @default.
- W1279103634 hasLocation W12791036344 @default.
- W1279103634 hasLocation W12791036345 @default.
- W1279103634 hasOpenAccess W1279103634 @default.
- W1279103634 hasPrimaryLocation W12791036341 @default.
- W1279103634 hasRelatedWork W1015051910 @default.
- W1279103634 hasRelatedWork W152576618 @default.
- W1279103634 hasRelatedWork W2136925628 @default.
- W1279103634 hasRelatedWork W2189534526 @default.
- W1279103634 hasRelatedWork W2221029685 @default.
- W1279103634 hasRelatedWork W2353498433 @default.
- W1279103634 hasRelatedWork W2354523586 @default.
- W1279103634 hasRelatedWork W2376234755 @default.
- W1279103634 hasRelatedWork W2601162058 @default.
- W1279103634 hasRelatedWork W15427406 @default.
- W1279103634 hasVolume "6" @default.
- W1279103634 isParatext "false" @default.
- W1279103634 isRetracted "false" @default.
- W1279103634 magId "1279103634" @default.
- W1279103634 workType "article" @default.