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- W12791158 abstract "Abstract After incubation of cholesterol-4-14C, cholest-5-ene-3β,7α-diol-7β-3H, and tritium-labeled 7α-hydroxycholest-4-en-3-one with the 20,000 x g supernatant fluid of rat liver homogenate, 7α,12α-dihydroxycholest-4-en-3-one was identified as one of the main metabolites. In the presence of microsomal fraction fortified with reduced nicotinamide adenine dinucleotide phosphate, 7α-hydroxycholest-4-en-3-one was converted into 7α,12α-dihydroxycholest-4-en-3-one as efficiently as in the 20,000 x g supernatant fluid. It is suggested that the main substrate for the 12α-hydroxylase in cholic acid formation might be 7α-hydroxycholest-4-en-3-one." @default.
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- W12791158 date "1966-04-01" @default.
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- W12791158 title "On the Conversion of Cholesterol to 7α,12α-Dihydroxycholest-4-en-3-one" @default.
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- W12791158 doi "https://doi.org/10.1016/s0021-9258(18)96731-1" @default.
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