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• W12791160 endingPage "68" @default.
• W12791160 startingPage "47" @default.
• W12791160 abstract "Nasal delivery is needle-free, non-invasive, and painless; it does not require sterile preparation, can be self-administered, and facilitates the rapid onset of both local and systemic drug action. In order to maximize patient compliance and expand/extend any existing patent position, the nasal route of administration is the focus of much attention as a non-invasive alternative to the peroral route and to invasive parenteral application. Moreover, the nose to brain pathway opens the door for targeting drugs to the central nervous system. The physical barrier of the nasal epithelium is the main limitation with respect to drug absorption, especially for large molecules such as proteins and peptides. Another important obstacle is the rapid mucociliary clearance which limits the time available for drug absorption. Enzymes (particularly proteases) that are present in the nasal mucosa and the mucus layer are of less importance (certainly when compared to oral delivery), but not negligible. Another possible drawback is the relatively small amount of drug that can be nasally administered; this is related to the method and technique of administration which, if poor, may lead to drug absorption problems depending on the actual site of drug deposition. To achieve a stable, safe, and effective nasal delivery of peptides and proteins, these limitations have to be overcome." @default.
• W12791160 created "2016-06-24" @default.
• W12791160 creator A5046705393 @default.
• W12791160 date "2011-01-01" @default.
• W12791160 modified "2023-10-13" @default.
• W12791160 title "Nasal Delivery of Peptides and Proteins with Chitosan and Related Mucoadhesive Polymers" @default.
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• W12791160 doi "https://doi.org/10.1016/b978-0-12-384935-9.10003-3" @default.
• W12791160 hasPublicationYear "2011" @default.
• W12791160 type Work @default.
• W12791160 sameAs 12791160 @default.

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