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- W127924508 abstract "This chapter discusses applications of macrophage electrophoretic migration (MEM) test. The MEM or MOD–MEM test has wide application in the whole field of medicine and biology wherever sensitization of lymphocytes is to be studied either as a pre- or postdisease phenomenon, provided certain stringent conditions are observed. Of paramount importance is the availability of pure antigens for testing, which do not themselves affect the mobility of the indicator macrophages. This may require skilled chromatographic purification. The field of ageing remains open for study using the MEM test in combination with modern biochemical separation methods for isolation and elucidation of antigenic determinant structure. As in cancer the cell surface appears to hold the key to ageing, of very special interest would be the use of the MEM test to study the effects of aging factors in both animals and man. The MEM test can be used for the study of common antigenic determinants and for elucidation of small changes in amino acid sequence in antigens. Thus, if guinea pigs are immunized with a small synthetic peptide and their lymphocytes tested with that same peptide, marked MEM slowing is obtained. The rapid MEM–MLR test can be applied to prospective studies and to select patients at the time of transplant. In the living donor situation, screening MLR tests are mainly performed and in the case of cadaver donors the test may be used to discriminate between two or three patients for a given kidney." @default.
- W127924508 created "2016-06-24" @default.
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- W127924508 date "1984-01-01" @default.
- W127924508 modified "2023-09-25" @default.
- W127924508 title "Macrophage Electrophoretic Migration (MEM) Test with Some Illustrative and Heuristic Applications" @default.
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- W127924508 doi "https://doi.org/10.1016/b978-0-12-564503-4.50010-5" @default.
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