Matches in SemOpenAlex for { <https://semopenalex.org/work/W127980765> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W127980765 endingPage "1376" @default.
- W127980765 startingPage "1372" @default.
- W127980765 abstract "This paper presents a novel multiscale modelling and simulation methodology for quantifying the simultaneous uptake of oxygen (O2) and nitric oxide (NO) in the human lungs and its application to predict pulmonary hypoxemia in methemoglobin anemia. The process of uptake of O2 and NO in the human lungs is a complex multiscale process, where the overall uptake at the macro scale (lung) is significantly influenced by the transport and reaction rate processes at the micro (red blood cell) and meso (capillary and alveolus) scales. We quantify the transport and reaction at the micro- and meso-scales by the fundamental convection-diffusion-reaction (CDR) equation and apply a spatial averaging technique (based on the Liapunov-Schmidt method of the classical bifurcation theory) to average the governing CDR equation over small length scales. The resultant easier-to-solve low-dimensional multiscale models embed each scale hierarchically within the other. We use this methodology to quantify hypoxemia in patients suffering from methemoglobin anemia - a disease caused when simultaneous uptake of O2 and NO results in abnormally high levels of methemoglobin (MetHb) in the red blood cell produced by irreversible NO-induced oxidation of the O2 carrying ferrous ion (Fe2+) in the heme group of the hemoglobin (Hb) molecule to its non-oxygen binding ferric state (Fe3+). Our simulations show that while breathing in room air, the O2 saturation in the patient's hemoglobin falls steadily from above 97% at 0 ppm NO to less than 94% at 50 ppm NO. We find that NO levels of 166 ppm or higher while breathing in room air may be be fatal for patients since it causes severe hypoxemia by decreasing the oxygen saturation to below its critical value of 90%. Our multiscale simulations predict that patients respond to oxygen therapy up to inhaled NO levels of about 216 ppm, above which they are candidates for methylene blue therapy." @default.
- W127980765 created "2016-06-24" @default.
- W127980765 creator A5039219915 @default.
- W127980765 creator A5078173437 @default.
- W127980765 date "2012-01-01" @default.
- W127980765 modified "2023-10-16" @default.
- W127980765 title "Multiscale Modelling and Simulation of simultaneous Oxygen and Nitric Oxide uptake in the Human Lungs and its application to Methemoglobin Anemia" @default.
- W127980765 cites W2055948651 @default.
- W127980765 cites W2081240040 @default.
- W127980765 cites W2586256972 @default.
- W127980765 doi "https://doi.org/10.1016/b978-0-444-59520-1.50133-0" @default.
- W127980765 hasPublicationYear "2012" @default.
- W127980765 type Work @default.
- W127980765 sameAs 127980765 @default.
- W127980765 citedByCount "0" @default.
- W127980765 crossrefType "book-chapter" @default.
- W127980765 hasAuthorship W127980765A5039219915 @default.
- W127980765 hasAuthorship W127980765A5078173437 @default.
- W127980765 hasConcept C126322002 @default.
- W127980765 hasConcept C178790620 @default.
- W127980765 hasConcept C185592680 @default.
- W127980765 hasConcept C26865036 @default.
- W127980765 hasConcept C2776557347 @default.
- W127980765 hasConcept C2776779939 @default.
- W127980765 hasConcept C2778248108 @default.
- W127980765 hasConcept C2778917026 @default.
- W127980765 hasConcept C2993864201 @default.
- W127980765 hasConcept C42219234 @default.
- W127980765 hasConcept C519581460 @default.
- W127980765 hasConcept C540031477 @default.
- W127980765 hasConcept C55493867 @default.
- W127980765 hasConcept C71924100 @default.
- W127980765 hasConceptScore W127980765C126322002 @default.
- W127980765 hasConceptScore W127980765C178790620 @default.
- W127980765 hasConceptScore W127980765C185592680 @default.
- W127980765 hasConceptScore W127980765C26865036 @default.
- W127980765 hasConceptScore W127980765C2776557347 @default.
- W127980765 hasConceptScore W127980765C2776779939 @default.
- W127980765 hasConceptScore W127980765C2778248108 @default.
- W127980765 hasConceptScore W127980765C2778917026 @default.
- W127980765 hasConceptScore W127980765C2993864201 @default.
- W127980765 hasConceptScore W127980765C42219234 @default.
- W127980765 hasConceptScore W127980765C519581460 @default.
- W127980765 hasConceptScore W127980765C540031477 @default.
- W127980765 hasConceptScore W127980765C55493867 @default.
- W127980765 hasConceptScore W127980765C71924100 @default.
- W127980765 hasLocation W1279807651 @default.
- W127980765 hasOpenAccess W127980765 @default.
- W127980765 hasPrimaryLocation W1279807651 @default.
- W127980765 hasRelatedWork W128295133 @default.
- W127980765 hasRelatedWork W1967745756 @default.
- W127980765 hasRelatedWork W1986670352 @default.
- W127980765 hasRelatedWork W2001806927 @default.
- W127980765 hasRelatedWork W2017402165 @default.
- W127980765 hasRelatedWork W2022768087 @default.
- W127980765 hasRelatedWork W2041818674 @default.
- W127980765 hasRelatedWork W2050817867 @default.
- W127980765 hasRelatedWork W2075723170 @default.
- W127980765 hasRelatedWork W2413323627 @default.
- W127980765 isParatext "false" @default.
- W127980765 isRetracted "false" @default.
- W127980765 magId "127980765" @default.
- W127980765 workType "book-chapter" @default.