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- W127987139 abstract "Delayed puberty is defined as the absence of any sign of puberty in a child at a chronologic age 2 standard deviations above the mean age of pubertal development for a given population. Normal puberty is initiated by the onset of pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. These pulses cause release of luteinizing hormone (LH) and follicular-stimulating hormone (FSH) from the pituitary gland. These pituitary gonadotropins then circulate to the gonads and stimulate production of sex steroids. The differential diagnosis of pubertal delay is extensive but can most easily be divided into three categories: The first group represents temporary delays of puberty that are functional disorders, most commonly, constitutional delay of growth and puberty. The second is hypogonadotropic hypogonadism, in which hypothalamic or pituitary failure results in deficiency of circulating gonadotropins. Finally, hypergonadotropic hypogonadism results from primary gonadal failure, with subsequent lack of negative feedback of sex steroids at the hypothalamic and pituitary levels resulting in elevated serum gonadotropin levels." @default.
- W127987139 created "2016-06-24" @default.
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- W127987139 date "2013-01-01" @default.
- W127987139 modified "2023-10-16" @default.
- W127987139 title "Turner Syndrome, Kallmann Syndrome and Noonan Syndrome" @default.
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