FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W128140714> ?p ?o ?g. }

• W128140714 abstract "Helicobacter pylori (H. pylori) is one of the most common bacterial infections in humans. There is a risk factor for gastric or duodenal ulcers, gastric cancer and MALT (Mucosa Associated Lymphoid Tissue)-Lymphomas. There are several invasive and non-invasive methods available for the diagnosis of H. pylori. The (13)C-urea breath test is a non-invasive method recommended for monitoring H. pylori eradication therapy. However, this test is not yet used for primary assessment of H. pylori in Germany.What are the clinical and health economic benefits of the (13)C-urea breath test in the primary assessment of H. pylori compared to other invasive and non-invasive methods?A systematic literature search including a hand search was performed for studies investigating test criteria and cost-effectiveness of the (13)C-urea breath test in comparison to other methods used in the primary assessment of H. pylori. Only studies that directly compared the (13)C-urea breath test to other H. pylori-tests were included. For the medical part, biopsy-based tests were used as the gold standard.30 medical studies are included. Compared to the immunoglobulin G (IgG) test, the sensitivity of the (13)C-urea breath test is higher in twelve studies, lower in six studies and one study reports no differences. The specificity is higher in 13 studies, lower in three studies and two studies report no differences. Compared to the stool antigen test, the sensitivity of the (13)C-urea breath test is higher in nine studies, lower in three studies and one study reports no difference. The specificity is higher in nine studies, lower in two studies and two studies report no differences. Compared to the urease test, the sensitivity of the (13)C-urea breath test is higher in four studies, lower in three studies and four studies report no differences. The specificity is higher in five studies, lower in five studies and one study reports no difference. Compared to histology, the sensitivity of the (13)C-urea breath test is higher in one study and lower in two studies. The specificity is higher in two studies and lower in one study. One study each compares the (13)C-urea breath test to the (14)C-urea breath test and the polymerase chain reaction (PCR) test, respectively, and reports no difference in sensitivity and specificity with the (14)C-urea breath test, and lower sensitivity and higher specificity compared to PCR. The statistical significance of these differences is described for six of the 30 studies. Nine health economic evaluations are included in the Health Technology Assessment (HTA) report. Among these studies, the test-and-treat strategy using the (13)C-urea breath test is compared to test-and-treat using serology in six analyses and to test and treat using the stool antigen test in three analyses. Thereby, test-and-treat using the breath test is shown to be cost-effective over the serology based strategy in three models and is dominated by a test-and-treat strategy using the stool antigen test in one model. A cost-effectiveness comparison between the urea breath test approach and the empirical antisecretory therapy is carried out in four studies. Of these, two studies report that the strategy using the urea breath test is cost-effective over the empirical antisecretory therapy. In two studies, test-and-treat using the (13)C-urea breath test is compared to the empirical eradication therapy and in five studies to endoscopy-based strategies. The breath test approach dominates endoscopy in two studies and is dominated by this strategy in one study.All included medical and economic studies are limited to a greater or lesser extent. Additionally, the results of the studies are heterogeneous regarding medical and economic outcomes respectively. Thus, the majority of the medical studies do not report the statistical significance of the differences in sensitivity and specificity. In direct comparisons the (13)C- urea breath test shows higher sensitivity and specificity than the IgG and stool antigen tests. In comparison to the urease test, results for sensitivity are inconsistent, and the specificity is slightly higher for the (13)C-urea breath test. There are not enough results for comparisons between the (13)C-urea breath test and the (14)C-urea breath test, histology and PCR to describe tendencies. The included economic studies suggest that the test-and-treat strategy using the (13)C-urea breath test is cost-effective compared to test-and-treat using serology as well as empirical antisecretory therapies. Due to a lack of valid studies, it is not possible to assess the breath test approach in comparison to test-and-treat using the stool antigen test and the empirical eradication therapy respectively, regarding the cost-effectiveness. The results of economic analyses comparing test-and-treat using the breath test to endoscopy strategies are too heterogeneous to draw any conclusions. Overall, none of the included economic models is able to completely capture the complexity of managing patients with dyspeptic complaints.Based on available medical and economic studies, there is no sufficient evidence to recommend test and-treat using (13)C-urea breath testing for the detection of H. pylori infection as the standard procedure for the management of uninvestigated dyspepsia in the German health care system. In addition, it must be considered that the DVGS guidelines of the Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DVGS) recommend endoscopy based methods for the management of patients with dyspeptic complaints." @default.
• W128140714 created "2016-06-24" @default.
• W128140714 creator A5008543007 @default.
• W128140714 creator A5013837204 @default.
• W128140714 creator A5031170346 @default.
• W128140714 creator A5041302341 @default.
• W128140714 creator A5065490844 @default.
• W128140714 creator A5067085127 @default.
• W128140714 creator A5087433482 @default.
• W128140714 date "2009-10-21" @default.
• W128140714 modified "2023-10-03" @default.
• W128140714 title "Efficacy and cost-effectiveness of the 13C-urea breath test as the primary diagnostic investigation for the detection of Helicobacter pylori infection compared to invasive and non-invasive diagnostic tests." @default.
• W128140714 doi "https://doi.org/10.3205/hta000076" @default.
• W128140714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3011289" @default.
• W128140714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21289901" @default.
• W128140714 hasPublicationYear "2009" @default.
• W128140714 type Work @default.
• W128140714 sameAs 128140714 @default.
• W128140714 citedByCount "13" @default.
• W128140714 countsByYear W1281407142012 @default.
• W128140714 countsByYear W1281407142014 @default.
• W128140714 countsByYear W1281407142015 @default.
• W128140714 countsByYear W1281407142016 @default.
• W128140714 countsByYear W1281407142017 @default.
• W128140714 countsByYear W1281407142018 @default.
• W128140714 countsByYear W1281407142019 @default.
• W128140714 countsByYear W1281407142020 @default.
• W128140714 countsByYear W1281407142021 @default.
• W128140714 countsByYear W1281407142023 @default.
• W128140714 crossrefType "journal-article" @default.
• W128140714 hasAuthorship W128140714A5008543007 @default.
• W128140714 hasAuthorship W128140714A5013837204 @default.
• W128140714 hasAuthorship W128140714A5031170346 @default.
• W128140714 hasAuthorship W128140714A5041302341 @default.
• W128140714 hasAuthorship W128140714A5065490844 @default.
• W128140714 hasAuthorship W128140714A5067085127 @default.
• W128140714 hasAuthorship W128140714A5087433482 @default.
• W128140714 hasConcept C126322002 @default.
• W128140714 hasConcept C2775934546 @default.
• W128140714 hasConcept C2775981797 @default.
• W128140714 hasConcept C2776409635 @default.
• W128140714 hasConcept C2777172195 @default.
• W128140714 hasConcept C2908868296 @default.
• W128140714 hasConcept C40993552 @default.
• W128140714 hasConcept C71924100 @default.
• W128140714 hasConcept C90924648 @default.
• W128140714 hasConceptScore W128140714C126322002 @default.
• W128140714 hasConceptScore W128140714C2775934546 @default.
• W128140714 hasConceptScore W128140714C2775981797 @default.
• W128140714 hasConceptScore W128140714C2776409635 @default.
• W128140714 hasConceptScore W128140714C2777172195 @default.
• W128140714 hasConceptScore W128140714C2908868296 @default.
• W128140714 hasConceptScore W128140714C40993552 @default.
• W128140714 hasConceptScore W128140714C71924100 @default.
• W128140714 hasConceptScore W128140714C90924648 @default.
• W128140714 hasLocation W1281407141 @default.
• W128140714 hasOpenAccess W128140714 @default.
• W128140714 hasPrimaryLocation W1281407141 @default.
• W128140714 hasRelatedWork W10424954 @default.
• W128140714 hasRelatedWork W154414202 @default.
• W128140714 hasRelatedWork W1984984931 @default.
• W128140714 hasRelatedWork W1989131633 @default.
• W128140714 hasRelatedWork W2058159022 @default.
• W128140714 hasRelatedWork W2060543030 @default.
• W128140714 hasRelatedWork W2064401560 @default.
• W128140714 hasRelatedWork W2101365507 @default.
• W128140714 hasRelatedWork W2111942462 @default.
• W128140714 hasRelatedWork W2115995739 @default.
• W128140714 hasRelatedWork W2125173799 @default.
• W128140714 hasRelatedWork W2141662724 @default.
• W128140714 hasRelatedWork W2144199211 @default.
• W128140714 hasRelatedWork W2152211277 @default.
• W128140714 hasRelatedWork W2161663236 @default.
• W128140714 hasRelatedWork W2167452382 @default.
• W128140714 hasRelatedWork W2527848138 @default.
• W128140714 hasRelatedWork W2948387191 @default.
• W128140714 hasRelatedWork W3022139801 @default.
• W128140714 hasRelatedWork W3144924484 @default.
• W128140714 isParatext "false" @default.
• W128140714 isRetracted "false" @default.
• W128140714 magId "128140714" @default.
• W128140714 workType "article" @default.