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- W128343072 abstract "Biomarkers are tools for the diagnosis, monitoring of therapy, and screening for a number of diseases. Biomarkers can also be used to detect disease risk factors allowing the physician to recommend or prescribe more intensive monitoring or testing of a patient. From a chemical and biochemical point of view, biomarker discovery uses a range of familiar techniques and tools such as SDS–PAGE, HPLC, and mass spectrometry. The ultimate goal of biomarker discovery is the development of screening tests to detect diseases before they are symptomatic or at a stage where they are more effectively treated. The data generated from the discovery of diagnostic biomarkers are valuable information for basic science and research into disease pathology. Information about changes in the concentration of a biomolecule, modified forms of a compound, changes in protein expression, and posttranslational modifications provide clues to the changes in the cellular machinery and pathways. This information can be used to determine where one should look for the changes that contribute to the disease pathology. The sample preparation methods and the separation techniques have to be developed carefully in order to facilitate the entire biomarker discovery process. Sample preparation methods should be compatible with the subsequent steps in the sample preparation process." @default.
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- W128343072 date "2008-01-01" @default.
- W128343072 modified "2023-09-27" @default.
- W128343072 title "Biomarker discovery" @default.
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- W128343072 doi "https://doi.org/10.1016/b978-044451980-1.50024-0" @default.
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