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• W128439093 abstract "Recent chromosome conformation capture experiments have led to the discovery of dense, contiguous, megabase-sized topological domains that are similar across cell types, are conserved across species. These domains are strongly correlated with a number of chromatin markers and have since been included in a number of analyses. However, functionally relevant domains may exist at multiple length scales. We introduce a new and efficient algorithm that is able to capture persistent domains across various resolutions by adjusting a single scale parameter. The identified novel domains are substantially different from domains reported previously and are highly enriched for insulating factor CTCF binding and histone modifications at the boundaries." @default.
• W128439093 created "2016-06-24" @default.
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• W128439093 date "2013-01-01" @default.
• W128439093 modified "2023-09-24" @default.
• W128439093 title "Multiscale Identification of Topological Domains in Chromatin" @default.
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• W128439093 doi "https://doi.org/10.1007/978-3-642-40453-5_23" @default.
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