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- W128530785 abstract "The aim of this thesis was to investigate the mechanisms of mammary tumor sensitization to anticancer drugs by omega 3 polyunsaturated fatty acid (n-3 PUFA). We showed that the increase in tumor cell sensitivity to mitoxantrone was associated with an enhancement in mitoxantrone uptake and a modification of the mitoxantrone distribution and metabolization within the cells. As we found that these last results involved oxidative stress, we examined the relation between chemosensitization by n-3 PUFA and tumor cells oxidative status. We found that n-3 PUFA decreased the activity of an anti-oxidant enzyme, the glutathione peroxidase, leading to an enhancement in lipid peroxidation. Finally, we showed in vivo that alterations of the vascular compartment organization (micro-, medium- and macro-vascularization) may occur for the effect of n-3 PUFA increasing taxanes efficacy. This thesis brought a major contribution to better understand the mechanisms involved in the chemosensitization by n-3 PUFA, such as tumor oxidative stress and tumor vascularization, and pave the way for new preclinical clinical studies dealing with the enhancement of anticancer therapy by n-3 PUFA." @default.
- W128530785 created "2016-06-24" @default.
- W128530785 creator A5074966932 @default.
- W128530785 date "2008-11-27" @default.
- W128530785 modified "2023-09-23" @default.
- W128530785 title "Augmentation de la sensibilité des cellules tumorales mammaires aux agents anticancéreux par les acides gras polyinsaturés n-3 : rôle du statut oxydant et de la vascularisation tumorale." @default.
- W128530785 hasPublicationYear "2008" @default.
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