FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W128547355> ?p ?o ?g. }

• W128547355 endingPage "41" @default.
• W128547355 startingPage "3237" @default.
• W128547355 abstract "Microtubules are involved in cell growth and division, motility, signalling and in the development and maintenance of cell shape. Consequently, the non-equilibrium dynamics of these microtubules can be crucial to cellular function, including cancer development. Although the involvement of tubulins in human development has been well investigated, the role of alpha- and beta-tubulins in human tumorigenesis still remains controversial. The aim of this study was to investigate alpha- and beta-tubulin protein expression in rectal cancer development.By immuno-histochemistry, using alpha- and beta-tubulin monoclonal antibodies, 66 patients were examined, 32 of whom (22 male, 10 female; range 31-60 years, mean age 49.5 years) had preneoplastic lesions discovered during endoscopic surveillance, which were classified as mild, moderate and severe dysplastic polyps of the rectum, and 34 had invasive adenocarcinomas (24 male, 10 female; range 39-60 years, mean 52 years) of the rectum, with no local or distant metastases at the time of surgical resection.In preneoplastic lesions, no statistically significant relationship was found among alpha- and beta-tubulin protein expression, grade of dysplasia, or other clinical data. Statistical association among alpha- and beta-tubulin immunoreactivity and Dukes' stages B and C was found with p = 0.017 and p = 0.009, respectively. No statistical relationship was found between alpha- and beta-tubulin protein expression among different grades of dysplasia. On the contrary, a significant relationship was detected among tubulins in different stages of cancer.In this preliminary study a significant difference of alpha- and beta-tubulin protein expressions was found in polyps and invasive cancer of the rectum, indicating a possible role of tubulins in invasive, but not in preinvasive cancer development. This preliminary data suggest the possibility of performing alpha- and beta-tubulin protein expression in order to identify B stage versus C stage rectal cancer, before surgical treatment." @default.
• W128547355 created "2016-06-24" @default.
• W128547355 creator A5001621165 @default.
• W128547355 creator A5009200286 @default.
• W128547355 creator A5023179463 @default.
• W128547355 creator A5024154243 @default.
• W128547355 creator A5024741952 @default.
• W128547355 creator A5033562790 @default.
• W128547355 creator A5044170850 @default.
• W128547355 creator A5046364104 @default.
• W128547355 creator A5051995527 @default.
• W128547355 creator A5070607229 @default.
• W128547355 creator A5085878437 @default.
• W128547355 date "2005-08-17" @default.
• W128547355 modified "2023-09-28" @default.
• W128547355 title "Alpha- and beta-tubulin expression in rectal cancer development." @default.
• W128547355 cites W1010739310 @default.
• W128547355 cites W1537655275 @default.
• W128547355 cites W1913492258 @default.
• W128547355 cites W1965404941 @default.
• W128547355 cites W1976300798 @default.
• W128547355 cites W1983112891 @default.
• W128547355 cites W2002737173 @default.
• W128547355 cites W2010051771 @default.
• W128547355 cites W2047578735 @default.
• W128547355 cites W2048990794 @default.
• W128547355 cites W2078342982 @default.
• W128547355 cites W2079125505 @default.
• W128547355 cites W2081406767 @default.
• W128547355 cites W2137171440 @default.
• W128547355 cites W2166492573 @default.
• W128547355 cites W2187101209 @default.
• W128547355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16101133" @default.
• W128547355 hasPublicationYear "2005" @default.
• W128547355 type Work @default.
• W128547355 sameAs 128547355 @default.
• W128547355 citedByCount "6" @default.
• W128547355 countsByYear W1285473552016 @default.
• W128547355 countsByYear W1285473552017 @default.
• W128547355 countsByYear W1285473552018 @default.
• W128547355 crossrefType "journal-article" @default.
• W128547355 hasAuthorship W128547355A5001621165 @default.
• W128547355 hasAuthorship W128547355A5009200286 @default.
• W128547355 hasAuthorship W128547355A5023179463 @default.
• W128547355 hasAuthorship W128547355A5024154243 @default.
• W128547355 hasAuthorship W128547355A5024741952 @default.
• W128547355 hasAuthorship W128547355A5033562790 @default.
• W128547355 hasAuthorship W128547355A5044170850 @default.
• W128547355 hasAuthorship W128547355A5046364104 @default.
• W128547355 hasAuthorship W128547355A5051995527 @default.
• W128547355 hasAuthorship W128547355A5070607229 @default.
• W128547355 hasAuthorship W128547355A5085878437 @default.
• W128547355 hasConcept C121608353 @default.
• W128547355 hasConcept C126322002 @default.
• W128547355 hasConcept C141071460 @default.
• W128547355 hasConcept C142724271 @default.
• W128547355 hasConcept C143998085 @default.
• W128547355 hasConcept C199360897 @default.
• W128547355 hasConcept C203014093 @default.
• W128547355 hasConcept C20418707 @default.
• W128547355 hasConcept C204232928 @default.
• W128547355 hasConcept C2775894508 @default.
• W128547355 hasConcept C2775944032 @default.
• W128547355 hasConcept C2776174256 @default.
• W128547355 hasConcept C2777546739 @default.
• W128547355 hasConcept C2781074409 @default.
• W128547355 hasConcept C41008148 @default.
• W128547355 hasConcept C49453240 @default.
• W128547355 hasConcept C502942594 @default.
• W128547355 hasConcept C526805850 @default.
• W128547355 hasConcept C54355233 @default.
• W128547355 hasConcept C555283112 @default.
• W128547355 hasConcept C64943373 @default.
• W128547355 hasConcept C71924100 @default.
• W128547355 hasConcept C84425145 @default.
• W128547355 hasConcept C86803240 @default.
• W128547355 hasConceptScore W128547355C121608353 @default.
• W128547355 hasConceptScore W128547355C126322002 @default.
• W128547355 hasConceptScore W128547355C141071460 @default.
• W128547355 hasConceptScore W128547355C142724271 @default.
• W128547355 hasConceptScore W128547355C143998085 @default.
• W128547355 hasConceptScore W128547355C199360897 @default.
• W128547355 hasConceptScore W128547355C203014093 @default.
• W128547355 hasConceptScore W128547355C20418707 @default.
• W128547355 hasConceptScore W128547355C204232928 @default.
• W128547355 hasConceptScore W128547355C2775894508 @default.
• W128547355 hasConceptScore W128547355C2775944032 @default.
• W128547355 hasConceptScore W128547355C2776174256 @default.
• W128547355 hasConceptScore W128547355C2777546739 @default.
• W128547355 hasConceptScore W128547355C2781074409 @default.
• W128547355 hasConceptScore W128547355C41008148 @default.
• W128547355 hasConceptScore W128547355C49453240 @default.
• W128547355 hasConceptScore W128547355C502942594 @default.
• W128547355 hasConceptScore W128547355C526805850 @default.
• W128547355 hasConceptScore W128547355C54355233 @default.
• W128547355 hasConceptScore W128547355C555283112 @default.
• W128547355 hasConceptScore W128547355C64943373 @default.
• W128547355 hasConceptScore W128547355C71924100 @default.

• next