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• W1285968 abstract "Regulatory machinery for gene expression, replication, and repair are architecturally organized in nuclear microenvironments. This compartmentalization provides threshold concentrations of macromolecules for the organization and assembly of regulatory complexes for combinatorial control. A mechanistic under standing of biological control requires the combined application of molecular, cellular, biochemical, and in vivo genetic approaches. This chapter provides methodologies to characterize nuclear organization of regulatory machinery by in situ immunofluorescence microscopy." @default.
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• W1285968 date "2008-01-01" @default.
• W1285968 modified "2023-10-17" @default.
• W1285968 title "In Situ Nuclear Organization of Regulatory Machinery" @default.
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• W1285968 doi "https://doi.org/10.1007/978-1-59745-104-8_17" @default.
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