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- W128696142 abstract "Ribozymes are ribonucleic acid (RNA) molecules capable of acting as enzymes even in the complete absence of proteins. They have the catalytic activity of breaking and/or forming covalent bonds with extraordinary specificity, accelerating the rate of these reactions. The ability of RNA to serve as a catalyst was first shown for the self-splicing group I intron of Tetrahymena and the RNA moiety of RNAse P (1–3). Subsequent to the discovery of these two RNA enzymes, RNA-mediated catalysis has been associated with the self-splicing group II introns of yeast, fungal, and plant mitochondria (as well as chloroplasts) (4); single-stranded plant viroid and virusoid RNAs (5–7); hepatitis delta virus (8); and a satellite RNA from Neurospora mitochondria (9). It is rather clear that the RNA component of the larger ribosomal subunit is functioning as a peptidyltransferase as well (10–13). The potential functioning of spliceosomal smaller nuclear (sn)RNAs as a ribozyme in complex with the premessenger RNA (pre-mRNA) to catalyze pre-mRNA splicing has also been proposed (14). It is highly likely that additional RNA catalytic motifs and new roles for RNA-mediated catalysis will also be found as more is learned about the genomes of a variety of organisms." @default.
- W128696142 created "2016-06-24" @default.
- W128696142 creator A5046038634 @default.
- W128696142 creator A5054862783 @default.
- W128696142 date "2007-11-02" @default.
- W128696142 modified "2023-10-10" @default.
- W128696142 title "Cancer Therapeutic Applications of Ribozymes and RNAi" @default.
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- W128696142 doi "https://doi.org/10.1007/978-1-59259-785-7_5" @default.
- W128696142 hasPublicationYear "2007" @default.