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- W128756398 abstract "Mechanical heart valves, specifically bileaflet valves, are widely applied to take place of diseased native valves. These prosthetic valve replacements exhibit good long-term mechanical durability. However, mechanical loading of blood is associated to complications (hemolysis and thrombogenicity), which represent important safety requirements for this kind of valves.In this thesis work, Particle Image Velocimetry (PIV) was applied as experimental tool for evaluating fluid dynamics characterization of biomedical implantable devices, especially for bileaflet mechanical heart valves (BMHVs). The procedures of PIV measurement of same target were repeatedly executed for multiple experimental validations of numerical data. The reproducibility of experimental data from PIV multiple measurements was proved reliable with the coefficients of variation for hemodynamic properties below 5%. These hemodynamic parameters such as velocity, turbulence shear stress (TSS) and hemolysis index (HI) did not only supply a good research basis for numerical simulation, but also directly analyze the potential risks for blood damages due to the artificial implantations. The maximum TSS captured in leakage jets of valve type 1 was around 40 Pa and that of valve type 2 was 20 Pa. The simulations using computational fluid dynamics (CFD) were carried out based on the physical parameters of experimental conditions. Good agreements between PIV and CFD were observed according to the comparisons in near-hinge regions. Furthermore, CFD data were used to investigate the hemodynamic properties inside of hinge region, where PIV measurements cannot be carried out due to optical inaccessibility. The experimental work was carried out entirely at the Istituto Superiore di Sanita (ISS) in Rome, Italy, whereas the simulation work was based on the cooperation between ISS and the Technical University of Cluj-Napoca (TuCN) in Cluj-Napoca, Romania. The final object of our cooperation is to take use of experimental and simulation methodologies to define a standard procedure for obtaining sufficient reliability in risk evaluation and mitigation of prosthetic heart valves." @default.
- W128756398 created "2016-06-24" @default.
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- W128756398 date "2013-01-30" @default.
- W128756398 modified "2023-09-27" @default.
- W128756398 title "Fluid dynamics characterization of biomedical implantable devices: experimental measurements and numerical simulation" @default.
- W128756398 hasPublicationYear "2013" @default.
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