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- W128756747 abstract "The acute effect of some neurotoxic compounds was examined on the rapid axonal transport of labelled proteins in rabbit vagus nerves in vitro. Hexachlorophene was a potent inhibitor of axonal transport giving a total block at 2×10−5M whereas millimolar concentrations (1×10−3M) of acrylamide and 2, 5-hexanedione had no effect on axonal transport. At high concentration (5×10−3M), however, acrylamide caused a total block, whereas 2, 5-hexanedione had no effect. To study the pathophysiology of nerve compression trauma, rabbit cervical vagus nerves were subjected to graded compression in vivo by means of a small compression chamber around the nerve and rapid axonal transport of labelled proteins was followed various times after compression. A pressure as low as 50 mmHg for 2 h acutely blocked the rapid axonal transport. Higher pressures (200 and 400 mmHg) applied for 2h induced more long-lasting blockades. The time required for recovery of transport was correlated to the magnitude of the pressure applied." @default.
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- W128756747 date "1978-01-01" @default.
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- W128756747 title "CHANGES IN AXONAL TRANSPORT IN VARIOUS EXPERIMENTAL NEUROPATHIES" @default.
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- W128756747 doi "https://doi.org/10.1016/b978-0-444-80079-4.50018-1" @default.
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