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- W128889859 abstract "Currently available techniques for sequencing DNA are inadequate for oligonucleotides of length greater than 600 nucleotides and are most effective in the 300 nucleotide range. Automated sequencers are now available which use, basically, the Sanger dideoxy termination method. The sequencing rates of these conventional methods are extremely low and involve very labor intensive procedures, requiring on the order of two man-years of effort for the determination of the sequence of a single 100 kilobase segment. Since the full human genetic complement is of vast size, representing {approximately} 3 {times} 10{sup 9} bases, a fast and accurate method for DNA sequencing is needed. Therefore, we set as a goal a sequencing rate in the range of {approximately} 10{sup 2} bp/s with an accuracy of {approximately} 1 error per 10{sup 6} bases, a value exceeding that set by the fidelity of current enzymatic processes. These values would permit the accurate determination of the sequence of the full human genome in one year. An approach involving rapid direct imaging of large segments of DNA is desired. A properly constructed x-ray Fourier-transform holographic microscope appears to combine these features. A basic x-ray holographic instrument has been designed. This concept, with appropriate modifications, and themore » use of presently available x-ray sources, appears applicable to the task of genome sequencing with a resulting rate of sequence determination in the range of {approximately} 10{sup 2} bp/s.« less" @default.
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- W128889859 date "1989-12-31" @default.
- W128889859 modified "2023-09-28" @default.
- W128889859 title "Genome sequencing by direct imaging x-ray color holography. Appendix A" @default.
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