Matches in SemOpenAlex for { <https://semopenalex.org/work/W129059858> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W129059858 endingPage "162" @default.
- W129059858 startingPage "153" @default.
- W129059858 abstract "Telomerase activity has been detected in a broad range of human malignant neoplasms, and its expression may represent an essential step in the malignant transformation of tissues; however, the expression of telomerase in premalignant lesions remains relatively unexplored. We tested tissue sections of cervical squamous cell carcinomas and squamous intraepithelial lesions, samples of benign reactive atypia, and normal cervical mucosa from hysterectomy and cone biopsy specimens for the expression of telomerase. Mirror-image sections from each sample were paraffin embedded and processed for histologic analysis. The test samples of cervical tissue were crushed under liquid nitrogen, and telomerase activity was determined by the telomeric repeat amplification protocol. Telomerase activity was detected in 18 of 18 cases (100%) of invasive squamous cell carcinoma. Twenty-five of 26 samples (96%) of high-grade squamous intraepithelial lesion also tested positively for telomerase activity, including 10 of 10 samples of moderate dysplasia, 12 of 13 samples of severe dysplasia, and 3 of 3 samples of carcinoma in situ. Telomerase activity was detected in 14 of 25 samples (56%) of low-grade squamous intraepithelial lesion and in 10 of 18 samples (56%) of reactive atypia but was detected in only 9 of 50 samples (18%) of histologically normal cervical mucosa. These results suggest that telomerase expression may be a marker of premalignant and malignant squamous cell lesions of the uterine cervix, although it is also expressed in a high proportion of cases of reactive atypia." @default.
- W129059858 created "2016-06-24" @default.
- W129059858 creator A5010856880 @default.
- W129059858 creator A5026505483 @default.
- W129059858 creator A5029982665 @default.
- W129059858 creator A5056238856 @default.
- W129059858 creator A5084710346 @default.
- W129059858 creator A5086099448 @default.
- W129059858 date "1998-02-01" @default.
- W129059858 modified "2023-09-27" @default.
- W129059858 title "Telomerase Expression in Normal Epithelium, Reactive Atypia, Squamous Dysplasia, and Squamous Cell Carcinoma of the Uterine Cervix" @default.
- W129059858 doi "https://doi.org/10.1093/ajcp/109.2.153" @default.
- W129059858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9583886" @default.
- W129059858 hasPublicationYear "1998" @default.
- W129059858 type Work @default.
- W129059858 sameAs 129059858 @default.
- W129059858 citedByCount "41" @default.
- W129059858 crossrefType "journal-article" @default.
- W129059858 hasAuthorship W129059858A5010856880 @default.
- W129059858 hasAuthorship W129059858A5026505483 @default.
- W129059858 hasAuthorship W129059858A5029982665 @default.
- W129059858 hasAuthorship W129059858A5056238856 @default.
- W129059858 hasAuthorship W129059858A5084710346 @default.
- W129059858 hasAuthorship W129059858A5086099448 @default.
- W129059858 hasConcept C104317684 @default.
- W129059858 hasConcept C121608353 @default.
- W129059858 hasConcept C126322002 @default.
- W129059858 hasConcept C142724271 @default.
- W129059858 hasConcept C2775894508 @default.
- W129059858 hasConcept C2775924586 @default.
- W129059858 hasConcept C2775934546 @default.
- W129059858 hasConcept C2776235491 @default.
- W129059858 hasConcept C2777343196 @default.
- W129059858 hasConcept C2777546739 @default.
- W129059858 hasConcept C2777661416 @default.
- W129059858 hasConcept C2777740455 @default.
- W129059858 hasConcept C2778220009 @default.
- W129059858 hasConcept C2779534503 @default.
- W129059858 hasConcept C2781283455 @default.
- W129059858 hasConcept C31033888 @default.
- W129059858 hasConcept C55493867 @default.
- W129059858 hasConcept C71924100 @default.
- W129059858 hasConcept C86803240 @default.
- W129059858 hasConcept C94581717 @default.
- W129059858 hasConceptScore W129059858C104317684 @default.
- W129059858 hasConceptScore W129059858C121608353 @default.
- W129059858 hasConceptScore W129059858C126322002 @default.
- W129059858 hasConceptScore W129059858C142724271 @default.
- W129059858 hasConceptScore W129059858C2775894508 @default.
- W129059858 hasConceptScore W129059858C2775924586 @default.
- W129059858 hasConceptScore W129059858C2775934546 @default.
- W129059858 hasConceptScore W129059858C2776235491 @default.
- W129059858 hasConceptScore W129059858C2777343196 @default.
- W129059858 hasConceptScore W129059858C2777546739 @default.
- W129059858 hasConceptScore W129059858C2777661416 @default.
- W129059858 hasConceptScore W129059858C2777740455 @default.
- W129059858 hasConceptScore W129059858C2778220009 @default.
- W129059858 hasConceptScore W129059858C2779534503 @default.
- W129059858 hasConceptScore W129059858C2781283455 @default.
- W129059858 hasConceptScore W129059858C31033888 @default.
- W129059858 hasConceptScore W129059858C55493867 @default.
- W129059858 hasConceptScore W129059858C71924100 @default.
- W129059858 hasConceptScore W129059858C86803240 @default.
- W129059858 hasConceptScore W129059858C94581717 @default.
- W129059858 hasIssue "2" @default.
- W129059858 hasLocation W1290598581 @default.
- W129059858 hasLocation W1290598582 @default.
- W129059858 hasOpenAccess W129059858 @default.
- W129059858 hasPrimaryLocation W1290598581 @default.
- W129059858 hasRelatedWork W129059858 @default.
- W129059858 hasRelatedWork W1991731181 @default.
- W129059858 hasRelatedWork W2005670739 @default.
- W129059858 hasRelatedWork W2045019615 @default.
- W129059858 hasRelatedWork W2064174372 @default.
- W129059858 hasRelatedWork W2074014993 @default.
- W129059858 hasRelatedWork W2086554538 @default.
- W129059858 hasRelatedWork W3161911199 @default.
- W129059858 hasRelatedWork W2285167560 @default.
- W129059858 hasRelatedWork W3113414916 @default.
- W129059858 hasVolume "109" @default.
- W129059858 isParatext "false" @default.
- W129059858 isRetracted "false" @default.
- W129059858 magId "129059858" @default.
- W129059858 workType "article" @default.