Matches in SemOpenAlex for { <https://semopenalex.org/work/W129113391> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W129113391 abstract "Platelets are small anucleate blood cells that plug holes in damage blood vessels. They do so by adhering to exposed extracellular matrix proteins at sites of injury and aggregating together. Platelet responsiveness to injury is controlled by a diverse repertoire of surface receptors that can be divided into two broad categories based on how they signal; the tyrosine kinased-linked receptors and the G protein-coupled receptors (GPCRs). There has been much work on elucidating the functions of tyrosine kinases in platelets, whereas protein tyrosine phosphatases (PTPs) have been under-investigated. To date, six non-transmembrane PTPs (NTPTPs), PTP-1B, Shp1, Shp2, MEG2-PTP, LMW-PTP and HePTP and a single receptor-like PTP (RPTP), CD148, have been identified in platelets. The main objective of this thesis was to determine the functional role of CD148 in platelets, which had never been studied in platelets. Using a mouse model, I demonstrate that CD148 is a critical positive regulator of signalling from the main collagen activation receptor GPVI and the fibrinogen integrin (alpha)II(beta)3, and also plays a minor role in regulating thrombin and thromboxane A(_) (TxA(_2) mediated aggregation and secretion via the PAR-4 and TP receptors, respectively. The molecular mechanism of how CD148 regulates signalling from so many receptors is by maintaining a pool of active Src family kinases (SFKs) in platelets, which it does by dephosphorylating a tyrosine residue in the C-terminal of all SFKs. In an attempt to identify other PTPs that perform a similar function to CD148 in platelets, I analyzed platelets from PTP-1B- and TC-PTP-deficient mouse models for functional and phosphorylation defects. PTP-1B-deficient platelets exhibited minor aggregation/secretion and phosphorylation defects relative to CD148-deficient platelets; and TC-PTP, which I show to be expressed in human and mouse platelets for the first time, is involved in platelet development. My conclusion is that CD148, PTP-1B and TC-PTP have distinct functional roles in platelets." @default.
- W129113391 created "2016-06-24" @default.
- W129113391 creator A5013137364 @default.
- W129113391 date "2010-07-01" @default.
- W129113391 modified "2023-09-27" @default.
- W129113391 title "CD148: a positive regulator of GPVI and (alpha)II(beta)3 proximal signalling in platelets" @default.
- W129113391 hasPublicationYear "2010" @default.
- W129113391 type Work @default.
- W129113391 sameAs 129113391 @default.
- W129113391 citedByCount "0" @default.
- W129113391 crossrefType "dissertation" @default.
- W129113391 hasAuthorship W129113391A5013137364 @default.
- W129113391 hasConcept C101544691 @default.
- W129113391 hasConcept C149577978 @default.
- W129113391 hasConcept C170493617 @default.
- W129113391 hasConcept C185592680 @default.
- W129113391 hasConcept C195687474 @default.
- W129113391 hasConcept C203014093 @default.
- W129113391 hasConcept C2777292125 @default.
- W129113391 hasConcept C2777553839 @default.
- W129113391 hasConcept C2780573682 @default.
- W129113391 hasConcept C2911166042 @default.
- W129113391 hasConcept C55493867 @default.
- W129113391 hasConcept C62478195 @default.
- W129113391 hasConcept C85528070 @default.
- W129113391 hasConcept C86803240 @default.
- W129113391 hasConcept C89560881 @default.
- W129113391 hasConcept C95444343 @default.
- W129113391 hasConceptScore W129113391C101544691 @default.
- W129113391 hasConceptScore W129113391C149577978 @default.
- W129113391 hasConceptScore W129113391C170493617 @default.
- W129113391 hasConceptScore W129113391C185592680 @default.
- W129113391 hasConceptScore W129113391C195687474 @default.
- W129113391 hasConceptScore W129113391C203014093 @default.
- W129113391 hasConceptScore W129113391C2777292125 @default.
- W129113391 hasConceptScore W129113391C2777553839 @default.
- W129113391 hasConceptScore W129113391C2780573682 @default.
- W129113391 hasConceptScore W129113391C2911166042 @default.
- W129113391 hasConceptScore W129113391C55493867 @default.
- W129113391 hasConceptScore W129113391C62478195 @default.
- W129113391 hasConceptScore W129113391C85528070 @default.
- W129113391 hasConceptScore W129113391C86803240 @default.
- W129113391 hasConceptScore W129113391C89560881 @default.
- W129113391 hasConceptScore W129113391C95444343 @default.
- W129113391 hasLocation W1291133911 @default.
- W129113391 hasOpenAccess W129113391 @default.
- W129113391 hasPrimaryLocation W1291133911 @default.
- W129113391 hasRelatedWork W1980046639 @default.
- W129113391 hasRelatedWork W2019251307 @default.
- W129113391 hasRelatedWork W2021156311 @default.
- W129113391 hasRelatedWork W2027377158 @default.
- W129113391 hasRelatedWork W2032243899 @default.
- W129113391 hasRelatedWork W2033093970 @default.
- W129113391 hasRelatedWork W2070730539 @default.
- W129113391 hasRelatedWork W2096936094 @default.
- W129113391 hasRelatedWork W2151862456 @default.
- W129113391 hasRelatedWork W2167327283 @default.
- W129113391 hasRelatedWork W2405204422 @default.
- W129113391 hasRelatedWork W2559589998 @default.
- W129113391 hasRelatedWork W2560912448 @default.
- W129113391 hasRelatedWork W2618932908 @default.
- W129113391 hasRelatedWork W2801671998 @default.
- W129113391 hasRelatedWork W2806900160 @default.
- W129113391 hasRelatedWork W3124293551 @default.
- W129113391 hasRelatedWork W3133663119 @default.
- W129113391 hasRelatedWork W3156525794 @default.
- W129113391 hasRelatedWork W3176408091 @default.
- W129113391 isParatext "false" @default.
- W129113391 isRetracted "false" @default.
- W129113391 magId "129113391" @default.
- W129113391 workType "dissertation" @default.