FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W129274562> ?p ?o ?g. }

• W129274562 endingPage "670" @default.
• W129274562 startingPage "665" @default.
• W129274562 abstract "Investigations were undertaken to see whether mouse keratinocyte differentiation was elicited by gangliosides. Among the gangliosides tested only GQ1b, a tetrasialoganglioside containing two disialosyl residues, induced keratinocyte differentiation, as indicated by the formation of cornified envelopes, enhancement of transglutaminase activity and suppression of DNA synthesis. Upon stimulation with GQ1b the mass content of Ins(1,4,5)P3 and the intracellular Ca2+ levels were markedly enhanced in a time- and dose-dependent manner, whereas no significant changes were observed with other gangliosides, thereby indicating activation of phospholipase C for the onset of keratinocyte differentiation. Furthermore, only GQ1b promoted the translocation of protein kinase C (PKC) from cytosol to membrane. Inhibition of PKC with H-7 or down-regulation of the enzyme by prolonged pre-treatment with phorbol 12,13-dibutyrate greatly suppressed transglutaminase activity and formation of cornified envelopes induced by GQ1b. These results demonstrate that the tetrasialoganglioside GQ1b generates the initial differentiation signal in mouse keratinocytes through phosphoinositide turnover, and also suggest that PKC activation may act at certain, as yet unidentified, stages of differentiation processes." @default.
• W129274562 created "2016-06-24" @default.
• W129274562 creator A5004361724 @default.
• W129274562 creator A5022300827 @default.
• W129274562 creator A5049786044 @default.
• W129274562 date "1991-11-01" @default.
• W129274562 modified "2023-09-23" @default.
• W129274562 title "Ganglioside GQ1b-induced terminal differentiation in cultured mouse keratinocytes. Phosphoinositide turnover forms the onset signal" @default.
• W129274562 cites W1538990103 @default.
• W129274562 cites W1553195773 @default.
• W129274562 cites W1569108584 @default.
• W129274562 cites W1625313056 @default.
• W129274562 cites W1935980239 @default.
• W129274562 cites W1973005880 @default.
• W129274562 cites W1975025978 @default.
• W129274562 cites W1977185700 @default.
• W129274562 cites W1979580749 @default.
• W129274562 cites W1990433146 @default.
• W129274562 cites W1993169352 @default.
• W129274562 cites W1993612650 @default.
• W129274562 cites W2024357543 @default.
• W129274562 cites W202711026 @default.
• W129274562 cites W2030627408 @default.
• W129274562 cites W2041416738 @default.
• W129274562 cites W2041460044 @default.
• W129274562 cites W2053175261 @default.
• W129274562 cites W2061843934 @default.
• W129274562 cites W2069771076 @default.
• W129274562 cites W2073638852 @default.
• W129274562 cites W2074521233 @default.
• W129274562 cites W2079438861 @default.
• W129274562 cites W2080360085 @default.
• W129274562 cites W2085296969 @default.
• W129274562 cites W2085352579 @default.
• W129274562 cites W2089101401 @default.
• W129274562 cites W2094807512 @default.
• W129274562 cites W2126625988 @default.
• W129274562 cites W2158246711 @default.
• W129274562 cites W2161229567 @default.
• W129274562 cites W2317560019 @default.
• W129274562 cites W609939700 @default.
• W129274562 cites W79597194 @default.
• W129274562 doi "https://doi.org/10.1042/bj2790665" @default.
• W129274562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1151496" @default.
• W129274562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1683230" @default.
• W129274562 hasPublicationYear "1991" @default.
• W129274562 type Work @default.
• W129274562 sameAs 129274562 @default.
• W129274562 citedByCount "26" @default.
• W129274562 crossrefType "journal-article" @default.
• W129274562 hasAuthorship W129274562A5004361724 @default.
• W129274562 hasAuthorship W129274562A5022300827 @default.
• W129274562 hasAuthorship W129274562A5049786044 @default.
• W129274562 hasBestOaLocation W1292745622 @default.
• W129274562 hasConcept C104317684 @default.
• W129274562 hasConcept C134018914 @default.
• W129274562 hasConcept C148738053 @default.
• W129274562 hasConcept C178498320 @default.
• W129274562 hasConcept C181199279 @default.
• W129274562 hasConcept C185592680 @default.
• W129274562 hasConcept C195794163 @default.
• W129274562 hasConcept C202751555 @default.
• W129274562 hasConcept C24998067 @default.
• W129274562 hasConcept C2777074287 @default.
• W129274562 hasConcept C2777331542 @default.
• W129274562 hasConcept C2778597717 @default.
• W129274562 hasConcept C55493867 @default.
• W129274562 hasConcept C62478195 @default.
• W129274562 hasConcept C79879829 @default.
• W129274562 hasConcept C86803240 @default.
• W129274562 hasConcept C95444343 @default.
• W129274562 hasConcept C98539663 @default.
• W129274562 hasConceptScore W129274562C104317684 @default.
• W129274562 hasConceptScore W129274562C134018914 @default.
• W129274562 hasConceptScore W129274562C148738053 @default.
• W129274562 hasConceptScore W129274562C178498320 @default.
• W129274562 hasConceptScore W129274562C181199279 @default.
• W129274562 hasConceptScore W129274562C185592680 @default.
• W129274562 hasConceptScore W129274562C195794163 @default.
• W129274562 hasConceptScore W129274562C202751555 @default.
• W129274562 hasConceptScore W129274562C24998067 @default.
• W129274562 hasConceptScore W129274562C2777074287 @default.
• W129274562 hasConceptScore W129274562C2777331542 @default.
• W129274562 hasConceptScore W129274562C2778597717 @default.
• W129274562 hasConceptScore W129274562C55493867 @default.
• W129274562 hasConceptScore W129274562C62478195 @default.
• W129274562 hasConceptScore W129274562C79879829 @default.
• W129274562 hasConceptScore W129274562C86803240 @default.
• W129274562 hasConceptScore W129274562C95444343 @default.
• W129274562 hasConceptScore W129274562C98539663 @default.
• W129274562 hasIssue "3" @default.
• W129274562 hasLocation W1292745621 @default.
• W129274562 hasLocation W1292745622 @default.
• W129274562 hasLocation W1292745623 @default.
• W129274562 hasLocation W1292745624 @default.
• W129274562 hasOpenAccess W129274562 @default.
• W129274562 hasPrimaryLocation W1292745621 @default.
• W129274562 hasRelatedWork W129274562 @default.

• next