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• W129343306 endingPage "206" @default.
• W129343306 startingPage "129" @default.
• W129343306 abstract "The term Quorum sensing (QS) was coined to describe the ability of bacteria to perceive and respond to population density for the collective regulation of gene expression, allowing social coordinated behaviors. Bacteria communicate using small chemicals called autoinducers (AIs) or pheromones. A high number of bacteria use QS systems which can control important functions, including pathogenicity processes, such as: antibiotic biosynthesis, virulence, plasmid conjugal transfer, swarming, endospores formation or biofilm differentiation. These signals allow the pathogens to coordinate the attack and beat the host defenses. The best studied QS signaling system involves N-acylhomoserine lactones (AHLs), that are constituted by an acyl chain N-bound to a homoserine lactone ring (HSL), the acyl chain confers variability to the molecule because it can change in length and substitutions. AHLs have been described as being exclusively produced by a relatively small number of α-, βand γ-Proteobacteria, but recently the production of these signals has been also reported for the colonial cyanobacterium Gloeothece and for several members of the phylum Bacteroidetes, which reinforces the role of AHL-mediated QS systems in natural populations and the study of the putative biotechnological applications of these processes. Since bacterial communication plays a key role in the control of many physiological functions in bacteria, including virulence on plants and animals, there is great interest in the design and implementation of systems to inactivate QS, a process also called Quorum quenching (QQ), which could function as a new antiphatogenic strategy. One of the major interests of the QQ approach is that it blocks the expression of the virulence factors but it does not exert selective pressure as it does not affect the pathogen survival, therefore avoiding the appearance of resistances. Although the inactivation of all QS systems is equally interesting, the QQ of AHLs is the best known to date. Therefore QQ has become an interesting alternative to antibiotic resistance in human health and in the aquaculture field. With the aim of study the frequency of QQ activity among marine bacteria and to obtain new strains with biotechnological potential, marine bacteria from a sediment of a fish culture tank; filtered marine water reservoir tank biofilm; 133 Revista Real Academia Galega de Ciencias. Vol. XXIX the algae Fucus vesiculosus, estuary marine water and open ocean water at 0 and 10 meters depth, were isolated in different media and temperatures. The high frequency of isolates with enzymatic degradation activity against AHL QS signals shows that QQ may be a common process among marine cultivable bacteria isolated from different marine environments, from near shore marine samples and from open ocean waters. Out of 630 bacterial isolates, 109 presented degradation activity against tested AHLs, which represents the 17.3% of the analysed isolates, almost an order of magnitude higher than obtained for soil isolates (2%). It has been possible to identify an isolate capable of antagonize AHL activity, although this activity still needs to be characterized. Culture media and isolating temperatures did not affect the percentage of QQ activity, while the sample origin strongly influenced QQ activity, being specially high for Fucus vesiculosus (39.4% active strains) and open ocean waters at 0 and 10 meters depth (27.7 and 27.7% respectively). Twenty isolates capable of interfereing the whole range of AHL sizes have been identified for their biotechnological potential, 15 among them were obtained from dense bacterial communities and 5 from marine water, most of them belonging to strictly marine genera. The isolates from near shore bacterial communities with wide spectrum QQ activity showed higher taxonomic variability, belonging to 10 genera classified in the phyla α-; γ-Proteobacteria (6, including a new species close to Phaeobacter); Actinobacteria (1); Firmicutes (2) and Bacteroidetes (1). The marine water isolates belonged to γ-Proteobacteria (1) and Bacteroidetes (2), including a new species close to Maribacter. It has been observed a high discrepancy between the number of isolates with QQ activity in marine waters and the frequency of QQ enzyme sequences in the available marine metagenomes. This discrepancy could be related to the low homology shown by QQ enzymes sequences or the existence of yet unknown QQ enzymatic activities. The study of the QQ activities present in the marine strains obtained in this study will surely extend our knowledge on new AHL degrading and inhibitory activities as well as it may drive to the development of biotechnological applications for the treatment and prevention of infections controlled by AHL-mediated QS processes, especially in the field of aquaculture, but also in human, animal and plant health. 134 Revista Real Academia Galega de Ciencias. Vol. XXIX" @default.
• W129343306 created "2016-06-24" @default.
• W129343306 creator A5000363407 @default.
• W129343306 creator A5081654371 @default.
• W129343306 date "2010-01-01" @default.
• W129343306 modified "2023-09-24" @default.
• W129343306 title "Interceptación de señales de comunicación bacteriana en bacterias aisladas del medio marino" @default.
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