Matches in SemOpenAlex for { <https://semopenalex.org/work/W129401182> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W129401182 abstract "The Organization of Excitation-Contraction (E-C) coupling mechanism is temporally regulated during heart remodelling. The molecular components involved in organizing membranes junctions with respect to the contractile apparatus remain elusive. SLMAP (Sarcolemmal Membrane Associated Protein) is a unique molecule shown to localize in cardiac membranes as well as the contractile apparatus and may serve to organizing the E-C coupling mechanism. The aim of this study was to investigate SLMAP expression and localization in developing myocardium and after Myocardial Infarction (MI) to correlate changes with any reorganization of the E-C coupling mechanism. SLMAP was located at the Z-disc, T-tubules and Sarcolemmal Membranes of rat myocardium as assessed by Immunostaining and Western blot analysis. SLMAP expression was significantly increased (p<0.005) from embryonic (E) day 16 to postnatal (P1) and gradually decreased (p<0.01) to low levels at 13 weeks. In a rat heart MI model induced by coronary ligation, SLMAP1 levels significantly increased (4 weeks post-surgery) in Infarct tissue vs. remote left ventricle (LV) (p<0.05) and SHAM (p<0.005). The location of SLMAP and temporal changes in its expression in normal and defective myocardium suggest that SLMAP may serve a role in organizing the E-C coupling apparatus during normal cardiac growth and in remodelling post MI. This work was supported by a grant from HSFO." @default.
- W129401182 created "2016-06-24" @default.
- W129401182 creator A5013474083 @default.
- W129401182 creator A5020772605 @default.
- W129401182 creator A5061861053 @default.
- W129401182 creator A5087812340 @default.
- W129401182 date "2007-01-01" @default.
- W129401182 modified "2023-09-23" @default.
- W129401182 title "Expression of the tail‐anchored protein SLMAP in developing myocardium and during remodelling after myocardial infarction" @default.
- W129401182 doi "https://doi.org/10.1096/fasebj.21.6.a1413-b" @default.
- W129401182 hasPublicationYear "2007" @default.
- W129401182 type Work @default.
- W129401182 sameAs 129401182 @default.
- W129401182 citedByCount "0" @default.
- W129401182 crossrefType "journal-article" @default.
- W129401182 hasAuthorship W129401182A5013474083 @default.
- W129401182 hasAuthorship W129401182A5020772605 @default.
- W129401182 hasAuthorship W129401182A5061861053 @default.
- W129401182 hasAuthorship W129401182A5087812340 @default.
- W129401182 hasConcept C104317684 @default.
- W129401182 hasConcept C126322002 @default.
- W129401182 hasConcept C164705383 @default.
- W129401182 hasConcept C179437574 @default.
- W129401182 hasConcept C185592680 @default.
- W129401182 hasConcept C204232928 @default.
- W129401182 hasConcept C2776415932 @default.
- W129401182 hasConcept C2778921608 @default.
- W129401182 hasConcept C2779537366 @default.
- W129401182 hasConcept C4224716 @default.
- W129401182 hasConcept C500558357 @default.
- W129401182 hasConcept C55493867 @default.
- W129401182 hasConcept C71924100 @default.
- W129401182 hasConceptScore W129401182C104317684 @default.
- W129401182 hasConceptScore W129401182C126322002 @default.
- W129401182 hasConceptScore W129401182C164705383 @default.
- W129401182 hasConceptScore W129401182C179437574 @default.
- W129401182 hasConceptScore W129401182C185592680 @default.
- W129401182 hasConceptScore W129401182C204232928 @default.
- W129401182 hasConceptScore W129401182C2776415932 @default.
- W129401182 hasConceptScore W129401182C2778921608 @default.
- W129401182 hasConceptScore W129401182C2779537366 @default.
- W129401182 hasConceptScore W129401182C4224716 @default.
- W129401182 hasConceptScore W129401182C500558357 @default.
- W129401182 hasConceptScore W129401182C55493867 @default.
- W129401182 hasConceptScore W129401182C71924100 @default.
- W129401182 hasIssue "6" @default.
- W129401182 hasLocation W1294011821 @default.
- W129401182 hasOpenAccess W129401182 @default.
- W129401182 hasPrimaryLocation W1294011821 @default.
- W129401182 hasRelatedWork W1966746871 @default.
- W129401182 hasRelatedWork W2023800627 @default.
- W129401182 hasRelatedWork W2045390961 @default.
- W129401182 hasRelatedWork W2068259322 @default.
- W129401182 hasRelatedWork W2075010150 @default.
- W129401182 hasRelatedWork W2098310315 @default.
- W129401182 hasRelatedWork W2399063111 @default.
- W129401182 hasRelatedWork W3000545198 @default.
- W129401182 hasRelatedWork W4200113697 @default.
- W129401182 hasRelatedWork W3032704255 @default.
- W129401182 hasVolume "21" @default.
- W129401182 isParatext "false" @default.
- W129401182 isRetracted "false" @default.
- W129401182 magId "129401182" @default.
- W129401182 workType "article" @default.