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- W129758189 abstract "This chapter discusses the role of proteases in myelin breakdown, axonal damage, and neuronal cell death in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). One such protease is the calcium-(Ca2+) activated neutral protease, calpain, which requires Ca2+ for activation. Ca2+ influx and calpain activation have been implicated in the neurodegenerative effects of many disorders of the central nervous system (CNS), including spinal cord injury (SCI), traumatic brain injury (TBI), Parkinson's disease, Alzheimer's disease, and ischemia. This chapter analyzes the current literature pertaining to the roles of calpain in the neurodegenerative events in MS and EAE. It first examines the roles of Ca2+-independent proteases. Altered Ca2+ influx via alterations in Ca2+ channels and glutamate excitotoxicity plays a role in pathogenesis. This chapter concludes that calpain is involved in axonal damage and neuronal death, and finally, the potential therapeutic effects that treatment with calpain inhibitors may have in MS and EAE are discussed." @default.
- W129758189 created "2016-06-24" @default.
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- W129758189 date "2005-01-01" @default.
- W129758189 modified "2023-09-23" @default.
- W129758189 title "Axonal Damage and Neuronal Death in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: The Role of Calpain" @default.
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- W129758189 doi "https://doi.org/10.1016/b978-012738761-1/50021-3" @default.
- W129758189 hasPublicationYear "2005" @default.
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