Matches in SemOpenAlex for { <https://semopenalex.org/work/W129780992> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W129780992 abstract "Human Parainfluenza virus type 3 (HPIV3) is a key respiratory pathogen responsible for bronchiolitis, pneumonia and croup. The persistent nature of this virus and its ability to reinfect within a short space of time has led to successive failures in the design of a vaccine against this virus. To understand the lack of protective immunity observed after HPIV3 infections, a comprehensive study investigating immune responses to this respiratory pathogen was undertaken. A human ex vivo model of viral infection was developed. Priming by HPIV3 was compared to immune responses induced by influenza A virus, which unlike HPIV3 primes immunity to reinfectionwith the same strain. HPIV3 infection generated potent and mature dendritic cells (DCs). However, unlike influenza A generated DCs, allogeneic human mixed leukocytes (MLR) failed to proliferate to HPIV3 generated DCs. Conversely pur3ed CD3+T cells were capable of expanding to these DCs. Further investigation revealed that autologous CD14-CD3- cells in the MLR were responsible for this control of T cell proliferation. Inhibition was contact dependent and reliant on the absence of IL-2. Follow on studies demonstrated that T cell proliferation control was due to CD56+ natural killer (NK) cells. Of interest, the regulation was not exerted by NK cytotoxicity but by partial arrest of cell cycle progression via regulation of p27 cyclin dependent kinase (cdk) inhibitor. Moreover, there was an overall control of T cell expansion by NK cells. The human ex vivo model was then used to assess the immunogenicity of a novel HPIV3 vaccine. Parallel studies involving murine immune models were also investigated. Studies revealed that the vaccine did not elicit the suppressive effects associated with HPIV3 whole virus infections. In conclusion, these studies identified a novel mechanism of immune regulation by NK cells in HPIV3 infections and demonstrated the potential of a novel vaccine against HPIV3." @default.
- W129780992 created "2016-06-24" @default.
- W129780992 creator A5088861832 @default.
- W129780992 date "2007-01-01" @default.
- W129780992 modified "2023-09-27" @default.
- W129780992 title "Modulation of immune responses by human paraininfluenza virus" @default.
- W129780992 hasPublicationYear "2007" @default.
- W129780992 type Work @default.
- W129780992 sameAs 129780992 @default.
- W129780992 citedByCount "0" @default.
- W129780992 crossrefType "dissertation" @default.
- W129780992 hasAuthorship W129780992A5088861832 @default.
- W129780992 hasConcept C100701293 @default.
- W129780992 hasConcept C159047783 @default.
- W129780992 hasConcept C203014093 @default.
- W129780992 hasConcept C59822182 @default.
- W129780992 hasConcept C81444415 @default.
- W129780992 hasConcept C86803240 @default.
- W129780992 hasConcept C8891405 @default.
- W129780992 hasConceptScore W129780992C100701293 @default.
- W129780992 hasConceptScore W129780992C159047783 @default.
- W129780992 hasConceptScore W129780992C203014093 @default.
- W129780992 hasConceptScore W129780992C59822182 @default.
- W129780992 hasConceptScore W129780992C81444415 @default.
- W129780992 hasConceptScore W129780992C86803240 @default.
- W129780992 hasConceptScore W129780992C8891405 @default.
- W129780992 hasLocation W1297809921 @default.
- W129780992 hasOpenAccess W129780992 @default.
- W129780992 hasPrimaryLocation W1297809921 @default.
- W129780992 hasRelatedWork W1973515935 @default.
- W129780992 hasRelatedWork W1992428625 @default.
- W129780992 hasRelatedWork W2025241942 @default.
- W129780992 hasRelatedWork W2031567383 @default.
- W129780992 hasRelatedWork W2095765326 @default.
- W129780992 hasRelatedWork W2110342824 @default.
- W129780992 hasRelatedWork W2113303991 @default.
- W129780992 hasRelatedWork W2119970185 @default.
- W129780992 hasRelatedWork W2137949247 @default.
- W129780992 hasRelatedWork W2142096105 @default.
- W129780992 hasRelatedWork W2170954538 @default.
- W129780992 hasRelatedWork W2247309918 @default.
- W129780992 hasRelatedWork W2463330250 @default.
- W129780992 hasRelatedWork W2565318179 @default.
- W129780992 hasRelatedWork W2606126638 @default.
- W129780992 hasRelatedWork W2790216561 @default.
- W129780992 hasRelatedWork W2957607587 @default.
- W129780992 hasRelatedWork W2991852999 @default.
- W129780992 hasRelatedWork W3193296610 @default.
- W129780992 hasRelatedWork W579620778 @default.
- W129780992 isParatext "false" @default.
- W129780992 isRetracted "false" @default.
- W129780992 magId "129780992" @default.
- W129780992 workType "dissertation" @default.