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- W1298070 abstract "This chapter provides an overview of endocrine disorders of growth. It focuses on hormonal signals produced by one cell type, released into the circulation, and influencing the growth or the function of cells in target tissues. The chapter outlines the steps involved in characterization of abnormal growth, applies them to an individual with profoundly abnormal growth, and discusses alternative explanations for the growth disturbance. Study of individuals whose growth departs from normal has produced important insights into the contributions of hormonal signaling to normal growth. The evaluation of a person who is unusually small or large for his or her age begins with the characterization of the growth phenotype. It continues with the measurement of the hormones known to influence growth or the hormonal phenotype. The chapter emphasizes that measurement of circulating levels of the relevant hormones is crucial in defining the intermediate phenotype. This term denotes the characteristics that lie between the cause of the disorder and its observed effects on growth. Different sets of hormones influence growth at different stages, so one needs to be selective in choosing which hormones to assess. To illustrate the application of principles underlying analysis of growth disorders, the chapter considers the case of a young woman of extremely short stature. Finally the chapter presents a comparison of genetic disorders at different points in the growth hormone axis, highlighting the effects of deficiency of growth hormone and other Anterior Pituitary hormones." @default.
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- W1298070 date "2002-01-01" @default.
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- W1298070 title "Endocrine Disorders of Growth" @default.
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- W1298070 doi "https://doi.org/10.1016/b978-012156651-7/50011-3" @default.
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