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- W129814733 abstract "The purpose of this section is to provide developmental purification strategies for recombinant proteins on a column of hydroxyapatite and then to optimize them for repeated purification cycles using effect additives. Surface neutralization solutions (SNS) (patent pending) and/or the addition of calcium ions reduce the solubility of hydroxyapatite thus extending the column lifetime. This section leads the user through purification protocol screening followed by SNS – calcium ion supplementation step gradients for purifying a monoclonal antibody from its contaminants. The section provides simple analytical tools using a 160 ml scale column to predict column life at the process scale. However, the development engineer is encouraged to test the model in a minimum-sized process column." @default.
- W129814733 created "2016-06-24" @default.
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- W129814733 date "2014-01-01" @default.
- W129814733 modified "2023-09-27" @default.
- W129814733 title "Hydroxyapatite Chromatography" @default.
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- W129814733 doi "https://doi.org/10.1016/b978-0-12-420119-4.00006-9" @default.
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