FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W130009105> ?p ?o ?g. }

• W130009105 endingPage "107.13" @default.
• W130009105 startingPage "107.13" @default.
• W130009105 abstract "Abstract Asthma is considered as a chronic pulmonary inflammatory disease, characterized by eosinophilia. Lung epithelium cells secrete CCL11, the major chemokine for the recruitment of eosinophils. Hybrid adeno-associated virus serotype 2/9 might achieve long-term gene delivery specifically to lung epithelium cells. Thus, this study tested whether hybrid AAV2/9 virus carrying shRNA specific for CCL11, sh47 and sh137, could reduce eosinophilia in a mite allergen-sensitized mouse model. Both sh47 and sh137 viruses significantly reduced CCL11 level in CCL11-transformed NIH 3T3 cells, compared with others. Both viruses were delivered into Dp2 (group 2 allergen of Dermatophagoides pteronyssinus) sensitized mice before first challenge. The results showed that sh47 virus significantly reduced airway resistance, airway hyperresponsiveness, CCL11 levels and eosinophilia in the lungs of Dp2-sensitized mice. Th2 cytokines were also significantly reduced in the bronchoalveolar lavage fluid and Dp2-stimulated mediastinal lymphocytes of sh47 virus-treated mice. However, serum levels of Dp2-specific IgG1 and IgE as well as Th2 cytokine levels in Dp2-stimulated splenocytes culture supernatants were at the comparable levels to the untreated group. The results suggest that sh47 virus relieved local instead of systemic inflammatory responses. Therefore, the hybrid AAV2/9 viral vector, which is preferable to target lung epithelia cells, might be applied as a novel therapeutic approach for asthma." @default.
• W130009105 created "2016-06-24" @default.
• W130009105 creator A5007159658 @default.
• W130009105 creator A5020668185 @default.
• W130009105 creator A5049568703 @default.
• W130009105 creator A5050411361 @default.
• W130009105 date "2011-04-01" @default.
• W130009105 modified "2023-09-25" @default.
• W130009105 title "Adeno-associated virus-mediated CCL11 shRNA reduced lung inflammatory responses in a mite allergen-sensitized mouse model (107.13)" @default.
• W130009105 cites W1922255142 @default.
• W130009105 cites W1963623233 @default.
• W130009105 cites W1967252203 @default.
• W130009105 cites W1978403614 @default.
• W130009105 cites W1992760418 @default.
• W130009105 cites W1995452016 @default.
• W130009105 cites W2002537198 @default.
• W130009105 cites W2007545557 @default.
• W130009105 cites W2012104351 @default.
• W130009105 cites W2017997885 @default.
• W130009105 cites W2020732371 @default.
• W130009105 cites W2033530205 @default.
• W130009105 cites W2042147187 @default.
• W130009105 cites W2053706844 @default.
• W130009105 cites W2057548071 @default.
• W130009105 cites W2058551642 @default.
• W130009105 cites W2067587032 @default.
• W130009105 cites W2091401210 @default.
• W130009105 cites W2111483225 @default.
• W130009105 cites W2114741749 @default.
• W130009105 cites W2125375279 @default.
• W130009105 cites W2136651927 @default.
• W130009105 cites W2140893753 @default.
• W130009105 cites W2151721675 @default.
• W130009105 cites W2166858952 @default.
• W130009105 cites W2416704227 @default.
• W130009105 cites W3007828221 @default.
• W130009105 cites W75541593 @default.
• W130009105 cites W77277417 @default.
• W130009105 cites W2071432321 @default.
• W130009105 doi "https://doi.org/10.4049/jimmunol.186.supp.107.13" @default.
• W130009105 hasPublicationYear "2011" @default.
• W130009105 type Work @default.
• W130009105 sameAs 130009105 @default.
• W130009105 citedByCount "0" @default.
• W130009105 crossrefType "journal-article" @default.
• W130009105 hasAuthorship W130009105A5007159658 @default.
• W130009105 hasAuthorship W130009105A5020668185 @default.
• W130009105 hasAuthorship W130009105A5049568703 @default.
• W130009105 hasAuthorship W130009105A5050411361 @default.
• W130009105 hasConcept C126322002 @default.
• W130009105 hasConcept C13373296 @default.
• W130009105 hasConcept C159047783 @default.
• W130009105 hasConcept C203014093 @default.
• W130009105 hasConcept C207480886 @default.
• W130009105 hasConcept C2522874641 @default.
• W130009105 hasConcept C2776042228 @default.
• W130009105 hasConcept C2776946954 @default.
• W130009105 hasConcept C2777037409 @default.
• W130009105 hasConcept C2777129736 @default.
• W130009105 hasConcept C2777714996 @default.
• W130009105 hasConcept C2777716647 @default.
• W130009105 hasConcept C2777961210 @default.
• W130009105 hasConcept C2778166374 @default.
• W130009105 hasConcept C2780510475 @default.
• W130009105 hasConcept C2780590879 @default.
• W130009105 hasConcept C71924100 @default.
• W130009105 hasConcept C86803240 @default.
• W130009105 hasConcept C8891405 @default.
• W130009105 hasConceptScore W130009105C126322002 @default.
• W130009105 hasConceptScore W130009105C13373296 @default.
• W130009105 hasConceptScore W130009105C159047783 @default.
• W130009105 hasConceptScore W130009105C203014093 @default.
• W130009105 hasConceptScore W130009105C207480886 @default.
• W130009105 hasConceptScore W130009105C2522874641 @default.
• W130009105 hasConceptScore W130009105C2776042228 @default.
• W130009105 hasConceptScore W130009105C2776946954 @default.
• W130009105 hasConceptScore W130009105C2777037409 @default.
• W130009105 hasConceptScore W130009105C2777129736 @default.
• W130009105 hasConceptScore W130009105C2777714996 @default.
• W130009105 hasConceptScore W130009105C2777716647 @default.
• W130009105 hasConceptScore W130009105C2777961210 @default.
• W130009105 hasConceptScore W130009105C2778166374 @default.
• W130009105 hasConceptScore W130009105C2780510475 @default.
• W130009105 hasConceptScore W130009105C2780590879 @default.
• W130009105 hasConceptScore W130009105C71924100 @default.
• W130009105 hasConceptScore W130009105C86803240 @default.
• W130009105 hasConceptScore W130009105C8891405 @default.
• W130009105 hasIssue "1_Supplement" @default.
• W130009105 hasLocation W1300091051 @default.
• W130009105 hasOpenAccess W130009105 @default.
• W130009105 hasPrimaryLocation W1300091051 @default.
• W130009105 hasRelatedWork W1979896799 @default.
• W130009105 hasRelatedWork W2005965749 @default.
• W130009105 hasRelatedWork W2008464566 @default.
• W130009105 hasRelatedWork W2038477076 @default.
• W130009105 hasRelatedWork W2083087446 @default.
• W130009105 hasRelatedWork W2104449005 @default.
• W130009105 hasRelatedWork W2122445545 @default.

• next