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- W130141886 abstract "Publisher Summary The explosion of information about the molecular basis of neoplastic transformation has provided numerous opportunities for progress in understanding and managing head and neck squamous cell carcinoma (HNSCC). With the advent of the polymerase chain reaction, small samples of DNA could be amplified to provide sufficient material for study. This technique, together with numerous sophisticated methods for manipulating DNA to gain insight into the function of individual genes, yields evidence for some of the decisive events that produce malignancy. An ideal tumor marker for molecular detection must have distinct attributes. It must be highly sensitive and highly specific and also able to distinguish between cancer and noncancerous tissue accurately. The event that produces the marker should occur relatively early in the malignant transformation process so that the appearance of the marker heralds the presence of disease at its initial stages. Methods for high-throughput analysis at low cost are on the horizon, including silicon-chip microarray technologies and fluorescent tags permitting automated detection. These methods can provide oncologists with an opportunity to identify patients during the earliest and most amenable stages for treatment and cure with the currently available treatment modalities." @default.
- W130141886 created "2016-06-24" @default.
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- W130141886 date "2003-01-01" @default.
- W130141886 modified "2023-09-25" @default.
- W130141886 title "Molecular Detection of Head and Neck Cancer" @default.
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- W130141886 doi "https://doi.org/10.1016/b978-012239990-9/50022-9" @default.
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