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- W130191569 abstract "Abstract : The progression of biochemical and morphological changes that occur following the transformation of a normal cell to a malignant cell have been poorly understood. There have been nine well-documented experimental protocols that have been developed and used to assess hepatocarcinogens (Faber and Sarma, 1987). One of these models has described a two-stage development of hepatocarcinogenesis in which a limited exposure to a potential carcinogen (initiation) is followed by a prolonged exposure to a second agent (promotion) (Peraino et al., 1973). Evidence has indicated that stimulation of cellular proliferation is required before the initiated cell can be detected (Cayama et al., 1978; Columbano, 1981), resulting in the occurrence of enzyme-altered foci (EAF)." @default.
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- W130191569 date "1990-04-01" @default.
- W130191569 modified "2023-09-28" @default.
- W130191569 title "Development of an Initiation/Promotion Assay to Detect Foci of Enzyme-Altered Hepatocytes" @default.
- W130191569 doi "https://doi.org/10.21236/ada221927" @default.
- W130191569 hasPublicationYear "1990" @default.
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