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- W130300462 abstract "Solid-phase combinatorial methods are evolving as an effective means for the generation of libraries of compounds in short time periods. These methods can expedite lead generation as well as lead optimization. Solid-phase organic synthesis (SPOS) has become an integral tool for the preparation of small molecule libraries. Several classes of compounds, exhibiting a wide range of biological activities [1], can be generated starting from the 2-amino-4-carboxy-thiophenol moiety. These include 3,4-dihydrobenzo-l,4-thiazines (1), 3,4-dihydrobenzo-l,4-thiazine-1,1 -dioxides (2), 3,4-dihy dro-3-oxobenzo-1,4-thiazines (3), 3,4-dihydro-3-oxobenzo-1,4-thiazine-1,1dioxides (4), and benzothiazoles (5). The core structures of these compounds contain many points at which diversity may be introduced." @default.
- W130300462 created "2016-06-24" @default.
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- W130300462 creator A5042329839 @default.
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- W130300462 date "2006-05-16" @default.
- W130300462 modified "2023-09-27" @default.
- W130300462 title "Solid-phase syntheses of libraries derived from 2-amino-4-carboxy-thiophenol moiety" @default.
- W130300462 doi "https://doi.org/10.1007/0-306-46881-6_80" @default.
- W130300462 hasPublicationYear "2006" @default.
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