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• W130481797 abstract "The aim of this study was to test the hypothesis that impaired calcium (Ca2+) recycling by sarcoplasmic reticulum (SR) Ca2+-ATPase takes place in aortae from 1 kidney–1 clip (1K-1C) hypertensive rats. The contractile response elicited when Ca2+ is released from the SR with phenylephrine and caffeine in Ca2+-free Krebs solution was greater in 1K-1C than in 1K rat aorta. In the arteries submitted to intracellular Ca2+ store depletion and reloading, this response was not different between 1K-1C and 1K rat aortae. Thapsigargin decreased the phasic contractile responses to phenylephrine in 1K and 1K-1C rat aortae and increased the tone that developed during the refilling period in 1K-1C rat aortae. Our data support the hypothesis that the 1K-1C rat aorta has defective intracellular Ca2+ regulation that may be implicated in an inadequate SR buffering ability." @default.
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• W130481797 date "1998-08-01" @default.
• W130481797 modified "2023-09-27" @default.
• W130481797 title "Alterations of Calcium Uptake in Renovascular Hypertensive Rat Aorta" @default.
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• W130481797 doi "https://doi.org/10.1016/s0306-3623(97)00445-x" @default.
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