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- W13056427 endingPage "24" @default.
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- W13056427 abstract "A limited number of somatic mutations are known to trigger malignancy via chronic activation of cellular signaling pathways. High-throughput analysis of gene expression in cancer cells has revealed a plethora of deregulated genes by far exceeding the number of known genetic alterations. Targeted tumor therapy takes advantage of deregulated signaling in cancer. However, cancer cells may evade successful therapy, e.g., targeting oncogenic kinases, due to mutation of the target protein or to resistance mechanisms acting downstream of or parallel to the therapeutic block. To improve therapy and molecular diagnostics, we need detailed information on the wiring of pathway components and targets that ultimately execute the malignant properties of advanced tumors. Here we review work on Ras-mediated signal transduction and Ras pathway- responsive targets. We introduce the concept of signal-regulated transcriptional modules comprising groups of target genes responding to individual branches of the pathway network. Furthermore, we discuss functional approaches based on RNA interference for elucidating critical nodes in oncogenic signaling and the targets essential for malignancy.KeywordsOvarian CarcinomaOvarian Surface EpitheliumLysyl OxidaseOncogenic Signaling PathwayOvarian Epithelial CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W13056427 created "2016-06-24" @default.
- W13056427 creator A5002711674 @default.
- W13056427 creator A5015836619 @default.
- W13056427 creator A5045102429 @default.
- W13056427 creator A5083876832 @default.
- W13056427 date "2007-06-08" @default.
- W13056427 modified "2023-10-18" @default.
- W13056427 title "Oncogenic Signaling Pathways and Deregulated Target Genes" @default.
- W13056427 cites W103445271 @default.
- W13056427 cites W1506680628 @default.
- W13056427 cites W1545398558 @default.
- W13056427 cites W1557061959 @default.
- W13056427 cites W1577974112 @default.
- W13056427 cites W1611419331 @default.
- W13056427 cites W1760280961 @default.
- W13056427 cites W1819766005 @default.
- W13056427 cites W1873117454 @default.
- W13056427 cites W1971727526 @default.
- W13056427 cites W1974104038 @default.
- W13056427 cites W1975693251 @default.
- W13056427 cites W1975728603 @default.
- W13056427 cites W1976441097 @default.
- W13056427 cites W1987572677 @default.
- W13056427 cites W1989968904 @default.
- W13056427 cites W1991346159 @default.
- W13056427 cites W1991920961 @default.
- W13056427 cites W1991954670 @default.
- W13056427 cites W1992177486 @default.
- W13056427 cites W1993163893 @default.
- W13056427 cites W1993653794 @default.
- W13056427 cites W1993830959 @default.
- W13056427 cites W1998262721 @default.
- W13056427 cites W2003886366 @default.
- W13056427 cites W2007446347 @default.
- W13056427 cites W2012617920 @default.
- W13056427 cites W2018548992 @default.
- W13056427 cites W2023427481 @default.
- W13056427 cites W2026440079 @default.
- W13056427 cites W2031363857 @default.
- W13056427 cites W2033697234 @default.
- W13056427 cites W2034059227 @default.
- W13056427 cites W2034269086 @default.
- W13056427 cites W2037677819 @default.
- W13056427 cites W2038492783 @default.
- W13056427 cites W2039828110 @default.
- W13056427 cites W2041098455 @default.
- W13056427 cites W2044428309 @default.
- W13056427 cites W2044474149 @default.
- W13056427 cites W2046542611 @default.
- W13056427 cites W2047800844 @default.
- W13056427 cites W2056683808 @default.
- W13056427 cites W2063957132 @default.
- W13056427 cites W2064393764 @default.
- W13056427 cites W2064988479 @default.
- W13056427 cites W2065332623 @default.
- W13056427 cites W2067427748 @default.
- W13056427 cites W2076981991 @default.
- W13056427 cites W2078237614 @default.
- W13056427 cites W2082438422 @default.
- W13056427 cites W2084336363 @default.
- W13056427 cites W2084633981 @default.
- W13056427 cites W2085776836 @default.
- W13056427 cites W2088170512 @default.
- W13056427 cites W2091258694 @default.
- W13056427 cites W2091587708 @default.
- W13056427 cites W2093531978 @default.
- W13056427 cites W2096570721 @default.
- W13056427 cites W2097261962 @default.
- W13056427 cites W2100924186 @default.
- W13056427 cites W2101354765 @default.
- W13056427 cites W2102802740 @default.
- W13056427 cites W2106119346 @default.
- W13056427 cites W2109363337 @default.
- W13056427 cites W2109970232 @default.
- W13056427 cites W2121627701 @default.
- W13056427 cites W2128985829 @default.
- W13056427 cites W2130594082 @default.
- W13056427 cites W2130651969 @default.
- W13056427 cites W2133881086 @default.
- W13056427 cites W2135200381 @default.
- W13056427 cites W2136447541 @default.
- W13056427 cites W2146536860 @default.
- W13056427 cites W2148188629 @default.
- W13056427 cites W2149538815 @default.
- W13056427 cites W2150926065 @default.
- W13056427 cites W2155612034 @default.
- W13056427 cites W2156417547 @default.
- W13056427 cites W2160006021 @default.
- W13056427 cites W2163188200 @default.
- W13056427 cites W2166802510 @default.
- W13056427 cites W2319602490 @default.
- W13056427 cites W2324384090 @default.
- W13056427 cites W2326889571 @default.
- W13056427 cites W2330797517 @default.
- W13056427 cites W2332104780 @default.
- W13056427 cites W238668910 @default.
- W13056427 cites W4240237951 @default.