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- W130624342 abstract "Publisher SummaryThis chapter discusses catecholamine action and immunologic reactivity. The cells of the immune system are capable of responding to antigen in vitro, independent of most physiologic influences present in an intact organism, and the proposal of a physiologic role for catecholamines does not imply that they can replace such requirements as antigen presentation, T-cell recognition of major histocompatibility complex products, or interleukin production. The role of the catecholamines in the effector phase of immunity must also be dissected more fully. The report of unequal distribution of β-adrenoceptors among T and B cells and among T-cell subpopulations, in conjunction with the apparent heterogeneity of lymphocyte cAMP responsiveness to β-adrenoceptor and of lymphocyte responses following a rise in intracellular cAMP, underscores the importance of identifying adrenoceptors and determining the efficiency of intracellular effector mechanism coupling in purified cell populations throughout the course of an immune response. It was suggested that these immunomodulators, which are considered external to the immune system, may participate in a cooperative effort to fine-tune the response to antigen, restraining proliferative and other effector processes where necessary to ensure that the magnitude of the response is roughly proportional to the amount of antigen encountered and that the ongoing response is appropriately terminated." @default.
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- W130624342 date "1991-01-01" @default.
- W130624342 modified "2023-09-26" @default.
- W130624342 title "Catecholamine Action and Immunologic Reactivity" @default.
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- W130624342 doi "https://doi.org/10.1016/b978-0-12-043780-1.50014-2" @default.
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