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- W130794044 abstract "Publisher Summary This chapter focuses on angiogenesis and (anti)angiogenic drugs. The formation of new blood vessels is an important process in embryonic development and in physiological processes, such as the cyclical changes in the endometrium during the menstrual cycle and the repair processes in wound healing. Two different mechanisms are involved in the formation of blood vessels—namely, (1) vasculogenesis : the development of blood vessels form in situ differentiating endothelial cells, and (2) angiogenesis : the sprouting of capillaries from existing vessels. Angiogenesis is the formation of capillaries from existing vessels. It follows a set program, starting with the disruption of basement membrane surrounding the endothelial cell layer. This is associated with the production of digestive enzymes such as collagenases and plasminogen activator by the endothelial cell. The combination of clinical need, the recognition of a range of potential molecular targets, and availability of biological assays has stimulated the synthesis of a wide range of (anti)angiogenic drugs. Various anti-angiogenic molecules include tyrosine kinase inhibitors, protamine, cyclosporin A, steroids, and heparins." @default.
- W130794044 created "2016-06-24" @default.
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- W130794044 date "1997-01-01" @default.
- W130794044 modified "2023-09-27" @default.
- W130794044 title "Angiogenesis and (anti)angiogenic drugs" @default.
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- W130794044 doi "https://doi.org/10.1016/s0165-7208(97)80085-2" @default.
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