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• W131445839 abstract "To analyze the protein expression essential for apoptosis in liver steatosis.The expression of proapoptotic proteins p53, Bax, and antiapoptotic Bcl-2 in hepatocytes with steatosis (SH) and without steatosis (NSH) was evaluated in 84 patients at various stages of non-alcoholic fatty liver disease (NAFLD).Immunohistochemical staining of liver tissue showed the activation of p53 protein in SH and NSH with increased liver steatosis, diminished Bcl-2 and slightly decreased Bax protein. Positive correlation was found between the stage of liver steatosis with p53 expression in SH (r = 0.54, P < 0.01) and NSH (r = 0.49, P < 0.01). The antiapoptotic protein Bcl-2 was diminished together with the advancement of liver steatosis, especially in non-steatosed hepatocytes (r = 0.43, P < 001).Apoptosis is one of the most important mechanisms leading to hepatocyte elimination in NAFLD. The intensification of inflammation in NAFLD induces proapoptotic protein p53 with the inhibition of antiapoptotic Bcl-2." @default.
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• W131445839 date "2006-01-01" @default.
• W131445839 modified "2023-09-26" @default.
• W131445839 title "Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease" @default.
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• W131445839 doi "https://doi.org/10.3748/wjg.v12.i38.6198" @default.
• W131445839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4088117" @default.
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