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• W131497406 endingPage "96" @default.
• W131497406 startingPage "75" @default.
• W131497406 abstract "The development of the mammalian cortex requires the generation, migration and differentiation of neurons. Each of these cellular events requires a dynamic microtubule cytoskeleton. Microtubules are required for interkinetic nuclear migration, the separation of chromatids in mitosis, nuclear translocation during migration and the outgrowth of neurites. Their importance is underlined by the finding that mutations in a host of microtubule associated proteins cause detrimental neurological disorders. More recently, the structural subunits of microtubules, the tubulin proteins, have been implicated in a spectrum of human diseases collectively known as the tubulinopathies. This chapter reviews the discovery of microtubules, the role they play in neurodevelopment, and catalogues the tubulin isoforms associated with neurodevelopmental disease. Our focus is on the molecular and cellular mechanisms that underlie the pathology of tubulin-associated diseases. Finally, we reflect on whether different tubulin genes have distinct intrinsic functions." @default.
• W131497406 created "2016-06-24" @default.
• W131497406 creator A5019788385 @default.
• W131497406 creator A5062455516 @default.
• W131497406 date "2013-10-17" @default.
• W131497406 modified "2023-10-18" @default.
• W131497406 title "Microtubules and Neurodevelopmental Disease: The Movers and the Makers" @default.
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